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Nuclear and mitocho...
Nuclear and mitochondrial DNA alterations in pheochromocytomas and paragangliomas, and their potential treatment
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- Tababi, Mouna (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Söderkvist, Peter (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Gimm, Oliver (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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(creator_code:org_t)
- BIOSCIENTIFICA LTD, 2023
- 2023
- Engelska.
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Ingår i: Endocrine-Related Cancer. - : BIOSCIENTIFICA LTD. - 1351-0088 .- 1479-6821. ; 30:1
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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visa fler...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Mitochondrial DNA (mtDNA) alterations have been reported in different types of cancers and are suggested to play important roles in cancer development and metastasis. However, there is little information about its involvement in pheochromocytomas and paragangliomas (PCCs/PGLs) formation. PCCs and PGLs are rare endocrine tumors of the chromaffin cells in the adrenal medulla and extra-adrenal paraganglia that can synthesize and secrete catecholamines. Over the last 3 decades, the genetic background of about 60% of PCCs/PGLs involving nuclear DNA alterations has been determined. Recently, a study showed that mitochondrial alterations can be found in around 17% of the remaining PCCs/PGLs. In this review, we summarize recent knowledge regarding both nuclear and mitochondrial alterations and their involvement in PCCs/PGLs. We also provide brief insights into the genetics and the molecular pathways associated with PCCs/PGLs and potential therapeutical targets.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- mtDNA; PCC/PGL; DNA alterations
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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