Sökning: id:"swepub:oai:DiVA.org:liu-192443" >
Safety of the use o...
Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in type 1 diabetes
-
- Tatovic, D (författare)
- Diabetes Research Group, Cardiff University School of Medicine , Cardiff , UK
-
- McAteer, M A (författare)
- Midatech Pharma PLC , Cardiff , UK
-
- Barry, J (författare)
- Midatech Pharma PLC , Cardiff , UK
-
visa fler...
-
- Barrientos, A (författare)
- Midatech Pharma PLC , Cardiff , UK
-
- Rodríguez Terradillos, K (författare)
- Midatech Pharma PLC , Cardiff , UK
-
- Perera, I (författare)
- Midatech Pharma PLC , Cardiff , UK
-
- Kochba, E (författare)
- NanoPass Technologies Ltd. , Nes Ziona , Israel
-
- Levin, Y (författare)
- NanoPass Technologies Ltd. , Nes Ziona , Israel
-
- Dul, M (författare)
- School of Pharmacy and Pharmaceutical Sciences, Cardiff University , Cardiff , UK
-
- Coulman, S A (författare)
- School of Pharmacy and Pharmaceutical Sciences, Cardiff University , Cardiff , UK
-
- Birchall, J C (författare)
- School of Pharmacy and Pharmaceutical Sciences, Cardiff University , Cardiff , UK
-
- von Ruhland, C (författare)
- Central Biotechnology Services, Cardiff University , Cardiff , UK
-
- Howell, A (författare)
- Diabetes Research Group, Cardiff University School of Medicine , Cardiff , UK
-
- Stenson, R (författare)
- Diabetes Research Group, Cardiff University School of Medicine , Cardiff , UK
-
- Alhadj Ali, M (författare)
- Diabetes Research Group, Cardiff University School of Medicine , Cardiff , UK
-
- Luzio, S D (författare)
- Diabetes Research Unit Cymru, Institute for Life Sciences, Swansea University , Swansea , UK
-
- Dunseath, G (författare)
- Diabetes Research Unit Cymru, Institute for Life Sciences, Swansea University , Swansea , UK
-
- Cheung, W Y (författare)
- Diabetes Research Unit Cymru, Institute for Life Sciences, Swansea University , Swansea , UK
-
- Holland, G (författare)
- Swansea Trials Unit, Swansea University Medical School , Swansea , UK
-
- May, K (författare)
- Department of Cellular Pathology, University Hospital of Wales , Cardiff , UK
-
- Ingram, J R (författare)
- Division of Infection & Immunity, Cardiff University School of Medicine , Cardiff , UK
-
- Chowdhury, M M U (författare)
- Welsh Institute of Dermatology, University Hospital of Wales , Cardiff , UK
-
- Wong, F S (författare)
- Diabetes Research Group, Cardiff University School of Medicine , Cardiff , UK
-
- Casas, Rosaura, 1954- (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
-
- Dayan, C (författare)
- Diabetes Research Group, Cardiff University School of Medicine , Cardiff , UK
-
- Ludvigsson, Johnny, 1943- (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
-
visa färre...
-
(creator_code:org_t)
- 2022-01-27
- 2022
- Engelska.
-
Ingår i: Immunotherapy Advances. - : Oxford University Press (OUP). - 2732-4303. ; 2:1
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Antigen-specific immunotherapy is an immunomodulatory strategy for autoimmune diseases, such as type 1 diabetes, in which patients are treated with autoantigens to promote immune tolerance, stop autoimmune β-cell destruction and prevent permanent dependence on exogenous insulin. In this study, human proinsulin peptide C19-A3 (known for its positive safety profile) was conjugated to ultrasmall gold nanoparticles (GNPs), an attractive drug delivery platform due to the potential anti-inflammatory properties of gold. We hypothesised that microneedle intradermal delivery of C19-A3 GNP may improve peptide pharmacokinetics and induce tolerogenic immunomodulation and proceeded to evaluate its safety and feasibility in a first-in-human trial. Allowing for the limitation of the small number of participants, intradermal administration of C19-A3 GNP appears safe and well tolerated in participants with type 1 diabetes. The associated prolonged skin retention of C19-A3 GNP after intradermal administration offers a number of possibilities to enhance its tolerogenic potential, which should be explored in future studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- gold nanoparticle; microneedle; peptide immunotherapy; proinsulin; type 1 diabetes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tatovic, D
-
McAteer, M A
-
Barry, J
-
Barrientos, A
-
Rodríguez Terrad ...
-
Perera, I
-
visa fler...
-
Kochba, E
-
Levin, Y
-
Dul, M
-
Coulman, S A
-
Birchall, J C
-
von Ruhland, C
-
Howell, A
-
Stenson, R
-
Alhadj Ali, M
-
Luzio, S D
-
Dunseath, G
-
Cheung, W Y
-
Holland, G
-
May, K
-
Ingram, J R
-
Chowdhury, M M U
-
Wong, F S
-
Casas, Rosaura, ...
-
Dayan, C
-
Ludvigsson, John ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Farmaceutiska ve ...
- Artiklar i publikationen
-
Immunotherapy Ad ...
- Av lärosätet
-
Linköpings universitet