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Contrast Enhanced M...
Contrast Enhanced Magnetic Resonance Imaging of Amyloid-beta Plaques in a Murine Alzheimers Disease Model
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- Sulheim, Einar (författare)
- Norwegian Univ Sci & Technol, Norway; SINTEF AS, Norway
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- Wideroe, Marius (författare)
- Norwegian Univ Sci & Technol, Norway
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- Bäck, Marcus (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Nilsson, Peter (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Hammarström, Per (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Nilsson, Lars N. G. (författare)
- Univ Oslo, Norway; Oslo Univ Hosp, Norway
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- Davies, Catharina de Lange (författare)
- Norwegian Univ Sci & Technol, Norway
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- Aslund, Andreas K. O. (författare)
- Norwegian Univ Sci & Technol, Norway; SINTEF AS, Norway
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(creator_code:org_t)
- IOS PRESS, 2023
- 2023
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - : IOS PRESS. - 1387-2877 .- 1875-8908. ; 93:2, s. 411-419
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Early detection of amyloid-beta(A beta) aggregates is a critical step to improve the treatment of Alzheimers disease (AD) because neuronal damage by the A beta aggregates occurs before clinical symptoms are apparent. We have previously shown that luminescent conjugated oligothiophenes (LCOs), which are highly specific towards protein aggregates of A beta, can be used to fluorescently label amyloid plaque in living rodents. Objective: We hypothesize that the LCO can be used to target gadolinium to the amyloid plaque and hence make the plaque detectable by T-1-weighted magnetic resonance imaging (MRI). Methods: A novel LCO-gadolinium construct was synthesized to selectively bind to A beta plaques and give contrast in conventional T-1-weighted MR images after intravenous injection in Tg-APPSwe mice. Results: We found that mice with high plaque-burden could be identified using the LCO-Gd constructs by conventional MRI. Conclusion: Our study shows that MR imaging of amyloid plaques is challenging but feasible, and hence contrast-mediated MR imaging could be a valuable tool for early AD detection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimers disease; amyloid-beta(A beta); fluorescence; magnetic resonance imaging; multimodal imaging
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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