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Lipid Extract from ...
Lipid Extract from Completely Sporoderm-broken Germinating Ganoderma sinensis Spores Elicits Potent Antitumor Immune Responses in Human Macrophages
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- Zhang, Jing-Ping (author)
- Sun Yat Sen University
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- Zheng, Limin (author)
- Sun Yat Sen University
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- Wang, Jiang-Hai (author)
- Sun Yat Sen University
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- Magnusson, Karl-Eric (author)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
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- Liu, Xin (author)
- Sun Yat Sen University
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(creator_code:org_t)
- Wiley, 2009
- 2009
- English.
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In: PHYTOTHERAPY RESEARCH. - : Wiley. - 0951-418X .- 1099-1573. ; 23:6, s. 844-850
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Ganoderma sinensis has been used widely in Oriental countries for the prevention and treatment of various diseases including cancer. Previous studies have shown that the lipid extract from Ganoderma exhibits direct cytotoxicity against tumor cells. Here, it is reported that the lipid extract from germinating G. sinensis spores, at lower concentrations that have no direct tumoricidal activity, induce potent antitumor immune responses in human monocytes/macrophages. Upon stimulation with the lipid extract, monocytes/macrophages exhibited markedly increased production of proinflammatory cytokines and surface expression of costimulatory molecules. Conditioned medium from stimulated cells effectively suppressed the growth of tumor cells. Apparently, the lipid extract triggered macrophage activation via a mechanism different from that associated with LPS. Moreover, it was observed that the lipid extract could partially re-establish the antitumor activity of the immunosuppressive tumor-associated macrophages. These results indicated that in addition to its direct tumoricidal activity, the lipid extract from G. sinensis spores could exert antitumor activity by stimulating the activation of human monocytes/macrophages.
Keyword
- antitumor immune response
- human monocytes/macrophages
- lipid extract
- germination
- Ganoderma sinensis spore
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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