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Eligibility for ver...
Eligibility for vericiguat in a real-world heart failure population according to trial, guideline and label criteria: Data from the Swedish Heart Failure Registry
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- Nguyen, Ngoc V. (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Lindberg, Felix (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Benson, Lina (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Ferrannini, Giulia (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Imbalzano, Egidio (författare)
- Univ Messina, Italy
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- Mol, Peter G. M. (författare)
- Univ Groningen, Netherlands
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- Dahlström, Ulf (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Rosano, Giuseppe M. C. (författare)
- IRCCS San Raffaele Roma, Italy
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- Ezekowitz, Justin (författare)
- Univ Alberta, Canada
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- Butler, Javed (författare)
- Univ Mississippi Med Ctr, MS USA; Baylor Scott & White Inst, TX USA
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- Lund, Lars H. (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Savarese, Gianluigi (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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(creator_code:org_t)
- WILEY, 2023
- 2023
- Engelska.
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Ingår i: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844. ; 25:8, s. 1418-1428
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aim We investigated the eligibility for vericiguat in a real-world heart failure (HF) population based on trial, guideline and label criteria. Methods and results From the Swedish HF registry, 23 573 patients with HF with reduced ejection fraction (HFrEF) enrolled between 2000 and 2018, with a HF duration >= 6months, were considered. Eligibility for vericiguat was calculated based on criteria from (i) the Vericiguat Global Study in Subjects with Heart Failure and Reduced Ejection Fraction (VICTORIA) trial; (ii) European and American guidelines on HF; (iii) product labelling according to the Food and Drug Administration and European Medicines Agency. Estimated eligibility for vericiguat in the trial, guidelines, and label scenarios was 21.4%, 47.4%, and 47.4%, respectively. Prior HF hospitalization within 6 months was the criterion limiting eligibility the most in all scenarios (met by 49.1% of the population). In the trial scenario, other criteria meaningfully limiting eligibility were elevated N-terminal pro-B-type natriuretic peptide levels and nitrate use. In all scenarios, eligibility was higher among patients hospitalized for HF at baseline (44.3% vs. 21.4% [trial scenario] and 97.3% vs. 47.4% [guideline/label scenarios] for hospitalized vs. non-hospitalized patients). Overall, eligible patients were older, had more severe HF, more comorbidities, and consequently higher cardiovascular mortality and HF hospitalization rates compared with ineligible patients across all scenarios. Conclusion In a large and contemporary real-world HFrEF cohort, we estimated that 21.4% of patients would be eligible for vericiguat according to the VICTORIA trial selection criteria, 47.4% based on guidelines and labelling. Eligibility for vericiguat translated into the selection of a population at high risk of morbidity/mortality. [GRAPHICS] .
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Heart failure; Vericiguat; Eligibility; Randomized controlled trial; Guidelines; Label
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- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nguyen, Ngoc V.
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Lindberg, Felix
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Benson, Lina
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Ferrannini, Giul ...
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Imbalzano, Egidi ...
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Mol, Peter G. M.
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Dahlström, Ulf
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Rosano, Giuseppe ...
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Ezekowitz, Justi ...
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Butler, Javed
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Lund, Lars H.
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Savarese, Gianlu ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Kardiologi
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European Journal ...
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Linköpings universitet
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Karolinska Institutet