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The impact of immun...
The impact of immunoglobulin G N-glycosylation level on COVID-19 outcome: evidence from a Mendelian randomization study
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- Long, Feiwu (författare)
- Sichuan Univ, Peoples R China
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- Xiao, Chenghan (författare)
- Sichuan Univ, Peoples R China
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- Cui, Huijie (författare)
- Sichuan Univ, Peoples R China
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- Wang, Wei (författare)
- Sichuan Univ, Peoples R China
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- Jiang, Zongze (författare)
- Sichuan Univ, Peoples R China
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- Tang, Mingshuang (författare)
- Sichuan Univ, Peoples R China
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- Zhang, Wenqiang (författare)
- Sichuan Univ, Peoples R China
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- Liu, Yunjie (författare)
- Sichuan Univ, Peoples R China
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- Xiang, Rong (författare)
- Sichuan Univ, Peoples R China
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- Zhang, Li (författare)
- Sichuan Univ, Peoples R China
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- Zhao, Xunying (författare)
- Sichuan Univ, Peoples R China
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- Yang, Chao (författare)
- Sichuan Univ, Peoples R China
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- Yan, Peijing (författare)
- Sichuan Univ, Peoples R China
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- Wu, Xueyao (författare)
- Sichuan Univ, Peoples R China
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- Wang, Yutong (författare)
- Sichuan Univ, Peoples R China
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- Zhou, Yanqiu (författare)
- Sichuan Univ, Peoples R China
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- Lu, Ran (författare)
- Sichuan Univ, Peoples R China
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- Chen, Yulin (författare)
- Sichuan Univ, Peoples R China
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- Li, Jiayuan (författare)
- Sichuan Univ, Peoples R China
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- Jiang, Xia (författare)
- Karolinska Institutet
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- Fan, Chuanwen (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Sichuan Univ, Peoples R China
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- Zhang, Ben (författare)
- Sichuan Univ, Peoples R China
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(creator_code:org_t)
- FRONTIERS MEDIA SA, 2023
- 2023
- Engelska.
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Ingår i: Frontiers in Immunology. - : FRONTIERS MEDIA SA. - 1664-3224. ; 14
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has exerted a profound influence on humans. Increasing evidence shows that immune response is crucial in influencing the risk of infection and disease severity. Observational studies suggest an association between COVID-19 and immunoglobulin G (IgG) N-glycosylation traits, but the causal relevance of these traits in COVID-19 susceptibility and severity remains controversial.MethodsWe conducted a two-sample Mendelian randomization (MR) analysis to explore the causal association between 77 IgG N-glycosylation traits and COVID-19 susceptibility, hospitalization, and severity using summary-level data from genome-wide association studies (GWAS) and applying multiple methods including inverse-variance weighting (IVW), MR Egger, and weighted median. We also used Cochrans Q statistic and leave-one-out analysis to detect heterogeneity across each single nucleotide polymorphism (SNP). Additionally, we used the MR-Egger intercept test, MR-PRESSO global test, and PhenoScanner tool to detect and remove SNPs with horizontal pleiotropy and to ensure the reliability of our results.ResultsWe found significant causal associations between genetically predicted IgG N-glycosylation traits and COVID-19 susceptibility, hospitalization, and severity. Specifically, we observed reduced risk of COVID-19 with the genetically predicted increased IgG N-glycan trait IGP45 (OR = 0.95, 95% CI = 0.92-0.98; FDR = 0.019). IGP22 and IGP30 were associated with a higher risk of COVID-19 hospitalization and severity. Two (IGP2 and IGP77) and five (IGP10, IGP14, IGP34, IGP36, and IGP50) IgG N-glycosylation traits were causally associated with a decreased risk of COVID-19 hospitalization and severity, respectively. Sensitivity analyses did not identify any horizontal pleiotropy.ConclusionsOur study provides evidence that genetically elevated IgG N-glycosylation traits may have a causal effect on diverse COVID-19 outcomes. Our findings have potential implications for developing targeted interventions to improve COVID-19 outcomes by modulating IgG N-glycosylation levels.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Mendelian randomization; COVID-19; IgG N-glycosylation; causality; inflammation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Long, Feiwu
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Xiao, Chenghan
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Cui, Huijie
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Wang, Wei
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Jiang, Zongze
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Tang, Mingshuang
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visa fler...
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Zhang, Wenqiang
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Liu, Yunjie
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Xiang, Rong
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Zhang, Li
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Zhao, Xunying
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Yang, Chao
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Yan, Peijing
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Wu, Xueyao
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Wang, Yutong
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Zhou, Yanqiu
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Lu, Ran
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Chen, Yulin
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Li, Jiayuan
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Jiang, Xia
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Fan, Chuanwen
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Zhang, Ben
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visa färre...
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Frontiers in Imm ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet