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Human endogenous ox...
Human endogenous oxytocin and its neural correlates show adaptive responses to social touch based on recent social context
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- Handlin, Linda (författare)
- Univ Skovde, Sweden
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- Novembre, Giovanni (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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- Lindholm, Helene (författare)
- Univ Skovde, Sweden
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- Kämpe, Robin (författare)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Paul, Elisabeth (författare)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Morrison, India (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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(creator_code:org_t)
- eLIFE SCIENCES PUBL LTD, 2023
- 2023
- Engelska.
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Ingår i: eLIFE. - : eLIFE SCIENCES PUBL LTD. - 2050-084X. ; 12
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- Both oxytocin (OT) and touch are key mediators of social attachment. In rodents, tactile stimulation elicits the endogenous release of OT, potentially facilitating attachment and other forms of prosocial behavior, yet the relationship between endogenous OT and neural modulation remains unexplored in humans. Using a serial sampling of plasma hormone levels during functional neuroimaging across two successive social interactions, we show that contextual circumstances of social touch influence not only current hormonal and brain responses but also later responses. Namely, touch from a male to his female romantic partner enhanced her subsequent OT release for touch from an unfamiliar stranger, yet females OT responses to partner touch were dampened following stranger touch. Hypothalamus and dorsal raphe activation reflected plasma OT changes during the initial social interaction. In the subsequent interaction, precuneus and parietal-temporal cortex pathways tracked time- and context-dependent variables in an OT-dependent manner. This OT-dependent cortical modulation included a region of the medial prefrontal cortex that also covaried with plasma cortisol, suggesting an influence on stress responses. These findings demonstrate that modulation between hormones and the brain during human social interactions can flexibly adapt to features of social context over time.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- oxytocin; touch; fMRI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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