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Patient-Reported Status and Heart Failure Outcomes in Asia by Sex, Ethnicity, and Socioeconomic Status

Lawson, Claire A (författare)
Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom; Leicester Real World Evidence Unit, Leicester, United Kingdom; NIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United Kingdom
Tay, Wan Ting (författare)
National Heart Centre Singapore, Singapore
Richards, Mark (författare)
Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Christchurch Heart Institute, University of Otago, Dunedin, New Zealand; National University Heart Centre, Singapore
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Zaccardi, Francesco (författare)
NIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United Kingdom; Diabetes Research Centre, Leicester, United Kingdom
Tromp, Jasper (författare)
National Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
Teng, Tiew-Hwa Katherine (författare)
National Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; School of Allied Health, University of Western Australia, Australia
Hung, Chung-Lieh (författare)
Department of Cardiology, MacKay Memorial Hospital, Taipei, Taiwan
Chandramouli, Chanchal (författare)
National Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore
Wander, Gurpreet S (författare)
Department of Cardiology, Hero Dayanand Medical College Heart Institute, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
Ouwerkerk, Wouter (författare)
National Heart Centre Singapore, Singapore; Department of Dermatology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands
Teramoto, Kanako (författare)
National Heart Centre Singapore, Singapore
Ali, Mohammad (författare)
Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom
Kadam, Umesh (författare)
Diabetes Research Centre, Leicester, United Kingdom; Department of Health Sciences, University of Leicester, Leicestershire, United Kingdom
Hand, Simon (författare)
Department of Health Sciences, University of Leicester, Leicestershire, United Kingdom
Harrison, Mary (författare)
Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
Anand, Inder (författare)
Cardiovascular Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Naik, Ajay (författare)
Care Institute of Medical Sciences, Ahmedabad, India
Squire, Iain (författare)
Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester, United Kingdom
Khunti, Kamlesh (författare)
Leicester Real World Evidence Unit, Leicester, United Kingdom; NIHR Applied Research Collaboration-East Midlands, University of Leicester, Leicester, United Kingdom; Diabetes Research Centre, Leicester, United Kingdom
Strömberg, Anna, 1967- (författare)
Linköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
Lam, Carolyn S P (författare)
National Heart Centre Singapore, Singapore; Duke-National University of Singapore Medical School, Singapore, Singapore; George Institute for Global Health, Sydney, Australia; Department of Cardiology, University of Groningen, Groningen, the Netherlands
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 (creator_code:org_t)
Elsevier, 2023
2023
Engelska.
Ingår i: JACC. Asia. - : Elsevier. - 2772-3747. ; 3:3, s. 349-362
Relaterad länk:
https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: In heart failure (HF), symptoms and health-related quality of life (HRQoL) are known to vary among different HF subgroups, but evidence on the association between changing HRQoL and outcomes has not been evaluated.Objectives: The authors sought to investigate the relationship between changing symptoms, signs, and HRQoL and outcomes by sex, ethnicity, and socioeconomic status (SES).Methods: Using the ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) Registry, we investigated associations between the 6-month change in a "global" symptoms and signs score (GSSS), Kansas City Cardiomyopathy Questionnaire overall score (KCCQ-OS), and visual analogue scale (VAS) and 1-year mortality or HF hospitalization.Results: In 6,549 patients (mean age: 62 ± 13 years], 29% female, 27% HF with preserved ejection fraction), women and those in low SES groups had higher symptom burden but lower signs and similar KCCQ-OS to their respective counterparts. Malay patients had the highest GSSS (3.9) and lowest KCCQ-OS (58.5), and Thai/Filipino/others (2.6) and Chinese patients (2.7) had the lowest GSSS scores and the highest KCCQ-OS (73.1 and 74.6, respectively). Compared to no change, worsening of GSSS (>1-point increase), KCCQ-OS (≥10-point decrease) and VAS (>1-point decrease) were associated with higher risk of HF admission/death (adjusted HR: 2.95 [95% CI: 2.14-4.06], 1.93 [95% CI: 1.26-2.94], and 2.30 [95% CI: 1.51-3.52], respectively). Conversely, the same degrees of improvement in GSSS, KCCQ-OS, and VAS were associated with reduced rates (HR: 0.35 [95% CI: 0.25-0.49], 0.25 [95% CI: 0.16-0.40], and 0.64 [95% CI: 0.40-1.00], respectively). Results were consistent across all sex, ethnicity, and SES groups (interaction P > 0.05).Conclusions: Serial measures of patient-reported symptoms and HRQoL are significant and consistent predictors of outcomes among different groups with HF and provide the potential for a patient-centered and pragmatic approach to risk stratification.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

health; heart failure; hospitalization; mortality; signs; symptoms

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