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Prenatal and postna...
Prenatal and postnatal exposure to antibiotics and risk of food allergy in the offspring: A nationwide birth cohort study in South Korea
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- Oh, Jiyeon (författare)
- Kyung Hee Univ, South Korea
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- Lee, Myeongcheol (författare)
- Kyung Hee Univ, South Korea
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- Park, Jaeyu (författare)
- Kyung Hee Univ, South Korea
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- Kim, Hyeon Jin (författare)
- Kyung Hee Univ, South Korea
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- Lee, Seung Won (författare)
- Sungkyunkwan Univ, South Korea
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- Rahmati, Masoud (författare)
- Lorestan Univ, Iran; Vali e Asr Univ Rafsanjan, Iran; Aix Marseille Univ, France
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- Koyanagi, Ai (författare)
- Parc Sanitari St Joan Deu, Spain
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- Smith, Lee (författare)
- Anglia Ruskin Univ, England
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- Kim, Min Seo (författare)
- Broad Inst MIT & Harvard, MA USA
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- Sanchez, Guillermo F. Lopez (författare)
- Univ Murcia, Spain
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- Dragioti, Elena (författare)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Univ Ioannina, Greece
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- Min, Chanyang (författare)
- Kyung Hee Univ, South Korea
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- Papadopoulos, Nikolaos G. (författare)
- Natl Kapodistrian Univ Athens, Greece; Univ Manchester, England
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- Shin, Youn Ho (författare)
- Catholic Univ Korea, South Korea
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- Shin, Jae Il (författare)
- Yonsei Univ, South Korea; Yonsei Univ, South Korea
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- Yon, Dong Keon (författare)
- Kyung Hee Univ, South Korea
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(creator_code:org_t)
- WILEY, 2024
- 2024
- Engelska.
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Ingår i: Pediatric Allergy and Immunology. - : WILEY. - 0905-6157 .- 1399-3038. ; 35:3
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background There are only preliminary studies examining the associations of postnatal antibiotic exposure with food allergy in childhood, and the effect of antibiotic exposure in utero has not been resolved. Thus, we aimed to investigate the effect of prenatal and postnatal antibiotic exposure on the risk of food allergy in childhood. Methods Using the nationwide birth cohort in South Korea, all 3,163,206 infants (pairing mother; n = 2,322,735) born in South Korea between 2010 and 2017 were included in the analysis. The primary outcome was the diagnosis of food allergy, and the observation period was between January 1, 2009, and December 31, 2020. We implemented four different designs for the study, which consisted of a full unmatched cohort, 1:1 propensity-matched cohort, sibling comparison cohort, and health screening cohort along with multiple subgroup analyses. Results During the follow-up period (median 6.92 years [IQR, 4.72-9.00]) of the 3,161,858 infants (52.6% male) in the birth cohort, 29,973 (1.9%) were diagnosed with food allergies. After a 1:1 propensity score matching, the use of antibiotics increased the risk of overall food allergy (prenatal [HR, 1.05; 95% CI, 1.04-1.09] and postnatal [HR, 1.05; 95% CI, 1.01-1.10] periods). The association was more significantly accentuated when antibiotic exposure was used in the short term, and the children were born preterm or with low birthweight; however, a trimester-specific effect was not observed. We observed more pronounced risks of food allergy in the health screening cohort (prenatal, 17%; postnatal, 15%), thus addressing the adverse effects of critical factors including maternal BMI, smoking status, and type of infant feeding. Similar trends were observed across all four differnt cohorts. Conclusion This study reported a moderate association between early-life antibiotic use and subsequent food allergy during childhood throughout four different designs of analyses. This study suggests that clinicians need to consider the risks and benefits of antibiotics when administering antibiotics to individuals in the prenatal and postnatal periods.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- antibiotics; children; food allergy; microbiome; pregnancy
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Oh, Jiyeon
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Lee, Myeongcheol
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Park, Jaeyu
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Kim, Hyeon Jin
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Lee, Seung Won
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Rahmati, Masoud
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Koyanagi, Ai
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Smith, Lee
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Kim, Min Seo
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Sanchez, Guiller ...
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Dragioti, Elena
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Min, Chanyang
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Papadopoulos, Ni ...
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Shin, Youn Ho
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Shin, Jae Il
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Yon, Dong Keon
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- MEDICIN OCH HÄLSOVETENSKAP
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Pediatric Allerg ...
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Linköpings universitet