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The influence of un...
The influence of undetected hemolysis on POCT potassium results in the emergency department
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- Tintu, Andrei N. (författare)
- Erasmus MC, Netherlands
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- Soto, Antonio Buno (författare)
- Hosp Univ La Paz, Spain
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- Van Hoof, Viviane (författare)
- Univ Antwerp, Belgium
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- Bench, Suzanne (författare)
- Guys & St Thomas NHS Trust, England
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- Malpass, Anthony (författare)
- Becton & Dickinson UK Ltd, England
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- Schilling, Martin (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Jourcentralen Linköping
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- Rooney, Kevin (författare)
- Royal Alexandra Hosp, Scotland
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- Oliver Saez, Paloma (författare)
- La Paz Cantoblanco Carlos III Univ Hosp, Spain
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- Relker, Lasse (författare)
- Eberhard Karls Univ Tubingen, Germany
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- Luppa, Peter (författare)
- Tech Univ Munich, Germany
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Clinical Chemistry and Laboratory Medicine. - : WALTER DE GRUYTER GMBH. - 1434-6621 .- 1437-4331.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives This study aimed to evaluate discrepancies in potassium measurements between point-of-care testing (POCT) and central laboratory (CL) methods, focusing on the impact of hemolysis on these measurements and its impact in the clinical practice in the emergency department (ED). Methods A retrospective analysis was conducted using data from three European university hospitals: Technische Universitat Munchen (Germany), Hospital Universitario La Paz (Spain), and Erasmus University Medical Center (The Netherlands). The study compared POCT potassium measurements in EDs with CL measurements. Data normalization was performed in categories for potassium levels (kalemia) and hemolysis. The severity of discrepancies between POCT and CL potassium measurements was assessed using the reference change value (RCV). Results The study identified significant discrepancies in potassium between POCT and CL methods. In comparing POCT normo- and mild hypokalemia against CL results, differences of -4.20 % and +4.88 % were noted respectively. The largest variance in the CL was a +4.14 % difference in the mild hyperkalemia category. Additionally, the RCV was calculated to quantify the severity of discrepancies between paired potassium measurements from POCT and CL methods. The overall hemolysis characteristics, as defined by the hemolysis gradient, showed considerable variation between the testing sites, significantly affecting the reliability of potassium measurements in POCT. Conclusions The study highlighted the challenges in achieving consistent potassium measurement results between POCT and CL methods, particularly in the presence of hemolysis. It emphasised the need for integrated hemolysis detection systems in future blood gas analysis devices to minimise discrepancies and ensure accurate POCT results.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Nyckelord
- point-of-care testing (POCT); blood gas analysis (BGA); preanalytical error; hemolysis; potassium
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tintu, Andrei N.
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Soto, Antonio Bu ...
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Van Hoof, Vivian ...
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Bench, Suzanne
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Malpass, Anthony
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Schilling, Marti ...
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visa fler...
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Rooney, Kevin
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Oliver Saez, Pal ...
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Relker, Lasse
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Luppa, Peter
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- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Medicinteknik
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och Medicinsk labora ...
- Artiklar i publikationen
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Clinical Chemist ...
- Av lärosätet
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Linköpings universitet