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Molecular epidemiol...
Molecular epidemiology of norovirus infections in Stockholm, Sweden, during the years 2000 to 2003 : Association of the GGIIb genetic cluster with infection in children
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- Tiveljung Lindell, Annika (författare)
- Karolinska Institutet
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- Grillner, Lena (författare)
- Karolinska Institutet
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- Svensson, Lennart, 1954- (författare)
- Linköpings universitet,Hälsouniversitetet,Molekylär virologi
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- Zweygberg Wirgart, Benita (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Journal of Clinical Microbiology. - 0095-1137 .- 1098-660X. ; 43:3, s. 1086-1092
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The incidence of norovirus-associated gastroenteritis and the molecular epidemiology of norovirus strains were studied during three seasons (2000-2001, 2001-2002, and 2002-2003) among patients of all ages, mainly from the Stockholm region in Sweden. A total of 3,252 fecal samples were analyzed by reverse transcription-PCR. The incidences of norovirus infection among adults were 23, 26, and 30% during the three seasons studied and 18,11, and 15% among children 0 to 15 years of age. During the first season, all norovirus strains detected by PCR were typed either by reverse line blot hybridization or nucleotide sequence analysis. During the two successive seasons, a total of 60 norovirus-positive strains from the beginning, peak, and end of the seasons were selected for nucleotide sequence analysis. We identified two dominant noroviras variants over the seasons: a new norovirus variant, recently described as the GGIIb genetic cluster, dominated among children during the first season, and during the following two seasons, a GGII-4 variant dominated. Our data suggest that norovirus infections are common, not only among adults, but also among children, and that some strains may predominantly affect children. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Nyckelord
- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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