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Lymphocytic colitis :
Lymphocytic colitis : a retrospective clinical study of 199 Swedish patients
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- Olesen, Martin, 1967- (författare)
- Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Eriksson, S. (författare)
- Department of Pathology, Örebro University Hospital, Örebro, Sweden
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- Bohr, J. (författare)
- Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Järnerot, Gunnar, 1935- (författare)
- Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Tysk, Curt, 1949- (författare)
- Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- BMJ, 2004
- 2004
- Engelska.
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Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 53:4, s. 536-541
- Relaterad länk:
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https://gut.bmj.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Lymphocytic colitis is characterised by chronic diarrhoea and specific microscopic changes in a macroscopically normal colonic mucosa. We report clinical features and treatment outcome in a large patient cohort.Methods: Patients were searched for in 24 Swedish gastroenterology clinics. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical notes.Results: Lymphocytic colitis was diagnosed in 199 cases. The female:male ratio was 2.4:1. Median age at diagnosis was 59 (48–70) years. The most frequent symptoms were diarrhoea (96%), abdominal pain (47%), and weight loss (41%). The course was chronic intermittent in 30% of patients, chronic continuous in 7%, and a single attack in 63%, and in these cases the disease duration was 6 (4–11) months. Seventy nine (40%) patients reported associated diseases, of which thyroid disorders, coeliac disease, and diabetes mellitus were the most common. In 34 first or second degree relatives of 24 (12%) patients, a family history of ulcerative colitis, Crohn’s disease, collagenous colitis, or coeliac disease was reported. Drug induced disease was suspected in 19 (10%) patients. A non-significant peak of disease onset was seen in December-January. More than 80% of treated patients improved on corticosteroids, including budesonide.Conclusions: A family history of other bowel disorders is a new finding. The sudden onset and single attack of limited duration may support a possible infectious cause in some cases. Drugs may cause lymphocytic colitis.
Nyckelord
- MEDICINE
- MEDICIN
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- art (ämneskategori)
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