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Division of labor a...
Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory
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- Wang, X.-J. (författare)
- Center for Complex Systems, Brandeis University, Waltham, MA 02254, United States
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- Tegnér, Jesper (författare)
- Karolinska Institutet,Linköpings universitet,Tekniska högskolan,Biologiska Beräkningar
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- Constantinidis, C. (författare)
- Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, United States, Wake Forest Univ. School of Medicine, Dept. of Neurobiology and Anatomy, Winston-Salem, NC 27157-1010, United States
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- Goldman-Rakic, P.S. (författare)
- Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, United States
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(creator_code:org_t)
- 2004-01-23
- 2004
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 101:5, s. 1368-1373
- Relaterad länk:
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http://www.pnas.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- A conspicuous feature of cortical organization is the wide diversity of inhibitory interneurons, their differential computational functions remain unclear. Here we propose a local cortical circuit in which three major subtypes of interneurons play distinct roles. In a model designed for spatial working memory, stimulus tuning of persistent activity arises from the concerted action of widespread inhibition mediated by perisoma-targeting (parvalbumin-containing) interneurons and localized disinhibition of pyramidal cells via interneuron-targeting (calretinin-containing) interneurons. Moreover, resistance against distracting stimuli (a fundamental property of working memory) is dynamically controlled by dendrite-targeting (calbindin-containing) interneurons. The experimental observation of inverted tuning curves of monkey prefrontal neurons recorded during working memory supports a key model prediction. This work suggests a framework for understanding the division of labor and cooperation among different inhibitory cell types in a recurrent cortical circuit.
Nyckelord
- TECHNOLOGY
- TEKNIKVETENSKAP
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