Elevated number of cells secreting transforming growth factor β in Guillain-Barré syndrome

• We used ELISPOT and cell ELISA to study secretion of IL-4, IFN-γ, TGF-β, IL-6, and TNF-α by circulating mononuclear cells during the course of Guillain-Barré syndrome (GBS). Compared to healthy controls, patients with GBS had higher numbers of TGF-β-secreting cells and the number of individuals with myelin-peptide-induced IL-4 and TGF-β secretion was higher in the GBS group. No significant differences were seen concerning the predominantly pro-inflammatory cytokines IFN-γ, IL-6 or TNF-α. Our findings indicate a down-regulatory role for TGF-β and IL-4 in GBS.

Keyword

Cytokines

ELISPOT

Guillain-Barré

IL-4

Syndrome

TGF-ß

MEDICINE

MEDICIN

Publication and Content Type

ref (subject category)

art (subject category)