Integrated approaches to uncovering transcription regulatory networks in mammalian cells

• Integrative systems biology has emerged as an exciting research approach in molecular biology and functional genomics that involves the integration of genomics, proteomics, and metabolomics datasets. These endeavors establish a systematic paradigm by which to interrogate, model, and iteratively refine our knowledge of the regulatory events within a cell. Here we review the latest technologies available to collect high-throughput measurements of a cellular state as well as the most successful methods for the integration and interrogation of these measurements. In particular we will focus on methods available to infer transcription regulatory networks in mammals.

Nyckelord

Bioinformatics

Cellular networks

ChIp-chip

Dynamics

Gene expression

Gene networks

Genomics

Networks

Personalized medicine

Protein interaction maps

Protein-protein interaction networks

Systems biology

Systems medicine

Transcriptional networks

TECHNOLOGY

TEKNIKVETENSKAP

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