Sökning: id:"swepub:oai:DiVA.org:liu-49022" >
Specific immunother...
Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma : 10-year follow-up on the PAT study
-
- Jacobsen, L. (författare)
- ALK-Abelló, Hørsholm, Denmark
-
- Niggemann, B. (författare)
- Department of Pediatric Pneumology and Immunology, Charité, Berlin, Germany
-
- Dreborg, S. (författare)
- Department of Pediatrics, University Hospital of Oslo, Oslo, Norway
-
visa fler...
-
- Ferdousi, Hosne Ara (författare)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
-
- Halken, S. (författare)
- Department of Pediatrics, Hospital of Sønderborg, Sønderborg, Denmark
-
- Høst, A. (författare)
- Department of Pediatrics, University Hospital of Odense, Odense, Denmark
-
- Koivikko, Antti (författare)
- Turku Allergy Centre, Turku, Finland
-
- Norberg, L.A. (författare)
- Department of Pediatrics, University Hospital of Odense, Odense, Denmark
-
- Valovirta, E. (författare)
- Turku Allergy Centre, Turku, Finland
-
- Wahn, U. (författare)
- Department of Pediatric Pneumology and Immunology, Charité, Berlin, Germany
-
- Möller, C. (författare)
- Umeå universitet,Pediatrik,Department of Pediatrics, Umeå University, Umeå, Sweden
-
visa färre...
-
(creator_code:org_t)
- Wiley, 2007
- 2007
- Engelska.
-
Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 62:8, s. 943-948
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: 3-year subcutaneous specific immunotherapy (SIT) in children with seasonal allergic rhinoconjunctivitis reduced the risk of developing asthma during treatment and 2 years after discontinuation of SIT (5-year follow-up) indicating long-term preventive effect of SIT.Objective: We evaluated the long-term clinical effect and the preventive effect of developing asthma 7-years after termination of SIT.Methods: One hundred and forty-seven subjects, aged 16–25 years with grass and/or birch pollen allergy was investigated 10 years after initiation of a 3-year course of SIT with standardized allergen extracts of grass and/or birch or no SIT respectively. Conjunctival provocations were performed outside the season and methacholine bronchial provocations were performed during the season and winter. Asthma was assessed by clinical evaluation.Results: The significant improvements in rhinoconjunctivitis and conjunctival sensitivity persisted at the 10-year follow-up. Significantly less actively treated subjects had developed asthma at 10-year follow-up as evaluated by clinical symptoms [odds ratio 2.5 (1.1–5.9)]. Patients who developed asthma among controls were 24/53 and in the SIT group 16/64. The longitudinal treatment effect when adjusted for bronchial hyper-responsiveness and asthma status at baseline including all observations at 3, 5 and 10 years follow-up (children with or without asthma at baseline, n = 189; 511 observations) was statistically significant (P = 0.0075). The odds ratio for no-asthma was 4.6 95% CI (1.5–13.7) in favor of SIT.Conclusion: A 3-year course of SIT with standardized allergen extracts has shown long-term clinical effects and the potential of preventing development of asthma in children with allergic rhinoconjunctivitis up to 7 years after treatment.Clinical implication: Specific immunotherapy has long-term clinical effects and the potential of preventing development of asthma in children with allergic rhino conjunctivitis up to 7 years after treatment termination.
Nyckelord
- Asthma
- Long-term effect
- Prevention
- Rhinitis
- Specific immunotherapy
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jacobsen, L.
-
Niggemann, B.
-
Dreborg, S.
-
Ferdousi, Hosne ...
-
Halken, S.
-
Høst, A.
-
visa fler...
-
Koivikko, Antti
-
Norberg, L.A.
-
Valovirta, E.
-
Wahn, U.
-
Möller, C.
-
visa färre...
- Artiklar i publikationen
-
Allergy. Europea ...
- Av lärosätet
-
Linköpings universitet
-
Umeå universitet