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Multivariate analys...
Multivariate analyses of flow cytometric S-phase and ploidy as node-negative breast cancer prognostic factors : an international and multi-center study
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Bagwell, CB (författare)
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Clark, GM (författare)
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Spyratos, F (författare)
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Chassevent, A (författare)
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Bendahl, PO (författare)
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- Stål, Olle (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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Killander, D (författare)
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Jourdan, ML (författare)
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Romain, S (författare)
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Hunsberger, CB (författare)
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Wright, S (författare)
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Baldetorp, B (författare)
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: Abstract Issue, 24th Annual San Antonio, Breast Cancer Symposium. December 10-13, 2001 San Antonio Marriott Rivercenter, Texas, USA.. ; , s. 260-260
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Recently a set of ten adjustments that optimizes the prognostic strength of both DNA ploidy (P) and S-phase (S) was published (Cytometry, 46(3), 2001). Also presented was an optimal method of combining P and S (P+S) that stratifies node-negative patients into highly significant risk groups. The adjustments compensate for many unappreciated complexities in categorizing P into low and high risk groups and eliminate unwanted correlation between P and S. The purpose of this study is to examine P+S in the context of other well-known prognostic factors such as primary size (pT), estrogen and progesterone receptor (ER,PR) and menopausal status (MS). Methods: DNA histograms derived from frozen primary tumors and clinical databases were provided by Baylor College, n=935; Sweden, n=210 (Lund, Linkoping, Stockholm) and France, n=220 (Angers, Marseille, Saint Cloud, Tours). Time to metastasis was the tested clinical outcome. Results: Cox proportional hazards analysis of theBaylor data revealed P+S, p<0.000002, and pT, p<0.003, as independent significant prognostic factors. The Sweden study also showed P+S the mostsignificant prognostic factor, p<0.002, as well as MS, p<0.004 and ER, p<0.007. The French study results were MS, p<0.0005, P+S, p<0.002 and pT, p<0.007.A P+S, MS and pT prognostic model stratified patients in all studies into highly significant categories, Baylor, p<0.000005, Sweden, p<0.00001, and French, p<0.000005, with low and high risk 10-year relapse-free survival fractions of 0.92-0.69, 0.95-0.58 and 0.96-0.60 respectively. Conclusion: A combined P+S, MS and pT prognostic model is a powerful and reliable method of stratifying node-negative breast cancer patients into highly significant prognostic groups.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)
- Av författaren/redakt...
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Bagwell, CB
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Clark, GM
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Spyratos, F
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Chassevent, A
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Bendahl, PO
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Stål, Olle
-
visa fler...
-
Killander, D
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Jourdan, ML
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Romain, S
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Hunsberger, CB
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Wright, S
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Baldetorp, B
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visa färre...
- Artiklar i publikationen
- Abstract Issue, ...
- Av lärosätet
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Linköpings universitet