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Extra-cellular matr...
Extra-cellular matrix proteins induce re-distribution of a-actinin-1 and a-actinin-4 in A431 cells
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- Bolshakova, A. (författare)
- Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation
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- Petukhova, O. (författare)
- Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation
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- Turoverova, L. (författare)
- Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation
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- Tentler, D. (författare)
- Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation
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- Babakov, V. (författare)
- Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation
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- Magnusson, Karl-Eric (författare)
- Linköpings universitet,Hälsouniversitetet,Medicinsk mikrobiologi
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- Pinaev, G. (författare)
- Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St. Petersburg, 194064, Russian Federation
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Department of Cell Cultures, Institute of Cytology, Tikhoretsky Avenue 4, St Petersburg, 194064, Russian Federation Hälsouniversitetet (creator_code:org_t)
- Wiley, 2007
- 2007
- Engelska.
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Ingår i: Cell Biology International. - : Wiley. - 1065-6995 .- 1095-8355. ; 31:4 SPEC. ISS., s. 360-365
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Alpha-actinins are actin-binding proteins of non-muscle cells, which can participate in the regulation of transcription factor activity. We describe the distribution of a-actinin-1 and -4 depending on different actin cytoskeleton formed as a result of cell adhesion to extracellular matrix proteins, such as fibronectin and laminin 2/4. Immunofluorescent studies show a difference in the distribution of a-actinin and -4. Both isoforms localise along stress-fibres, but a-actinin-1 localises in the perinuclear region more abundantly than a-actinin-4. Western blot analysis demonstrated existence of truncated forms of both isoforms. Truncated a-actinin-1 appears in cells spread on fibronectin or laminin. Cell spreading also correlated with more tight association of a-actinin-4 with chromatin. Basing on our previous finding of an interaction of a-actinin-4 with p65 subunit of the NF-?B, we checked the possible influence of immobilised ligands on its redistribution in nuclear complexes containing p65. a-Actinin-4 seems to be present in some but not all nuclear complexes containing p65. Immobilised ligands may affect the interaction of a-actinin-4/p65 complexes with chromatin. The data suggest that adhesion to extra-cellular matrix may interfere in cellular reactions mediated by a-actinin-1 and -4. © 2007 International Federation for Cell Biology.
Nyckelord
- a-Actinin-1
- a-Actinin-4
- Actin cytoskeleton
- Extra-cellular matrix
- NF-?B
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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