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A structural model ...
A structural model of human steroid 11-betahydroxylase,CYP11B1, used to predict consequences of mutations
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- Carlsson, Jonas, 1979- (författare)
- Linköpings universitet,Bioinformatik,Tekniska högskolan
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- Wedell, Anna (författare)
- Department of Molecular Medicine and Surgery, CMM:02, Karolinska Institutet/Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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- Persson, Bengt (författare)
- Linköpings universitet,Bioinformatik,Tekniska högskolan
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- A prediction method has been developed to estimate the severity of amino acid residue exchanges in human steroid 11-beta-hydroxylase, CYP11B1, due to mutations in the corresponding gene. The prediction is based both on structural and on sequence dependent parameters. The method uses two approaches; one with general molecular property weights and one with a consensus voting strategy based upon distribution of molecular properties, which does not require any training. Both methods are tested on known mutations in CYP11B1 and result in 85% prediction accuracy. The consensus voting method is then further evaluated on 9 proteins with an average of 81% prediction accuracy. A server utilizing the results from the consensus voting on CYP11B1 is provided where the user can extract information about new mutants. A similar server is also provided for mutants in human steroid 21-hydroxylase (CYP21).
Nyckelord
- CYP11B1
- steroid 11-beta-hydroxylase
- molecular modeling
- structural prediction
- mutations
- NATURAL SCIENCES
- NATURVETENSKAP
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