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Neutrophil-derived ...
Neutrophil-derived heparin binding protein-A mediator of increased vascular permeability after burns?
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- Johansson, Joakim (författare)
- Umeå universitet,Linköpings universitet,Institutionen för medicin och hälsa,Hälsouniversitetet,Anestesiologi och intensivvård,Department of Perioperative Medicine, Faculty of Health Sciences, Linköping University Hospital, Linköping, Sweden
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- Lindbom, Lennart (författare)
- Karolinska Institutet,Karolinska Institute, Department Physiol and Pharmacol, Stockholm, Sweden
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- Herwald, Heiko (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Department Clin Science, Div Infect Med, Lund, Sweden
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- Sjoberg, Folke (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Brännskadevård,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: BURNS. - : Elsevier BV. - 0305-4179 .- 1879-1409. ; 35:8, s. 1185-1187
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Increased vascular permeability and oedema formation constitute a major clinical challenge following burns. Several clinical studies show that leukocytes are systemically activated following burns. Neutrophils have the capability to increase vascular permeability via mechanisms thought to involve the release of heparin binding protein (HBP). We hypothesised that HBP is elevated in plasma after major burns due to a systemic inflammatory response and investigated plasma-HBP concentrations in 10 severely burned patients daily for 1 week following the burn. Five-fold higher levels in plasma-HBP concentration compared to a control group were detected on the first day after injury, followed by a steep reduction in the time-period that corresponds to the last part of the hyperpermeability phase. These data are in accordance with the hypothesis that HBP may function as a mediator of the early bum-induced increase in vascular permeability, and call for further studies to confirm a possible cause-and-effect relationship between HBP and oedema formation following burns.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Azurocidin
- Burn
- CAP-37
- HBP
- Trauma
- Vascular permeability
- TECHNOLOGY
- TEKNIKVETENSKAP
- Vascular permeability
- Trauma
- HBP
- CAP-37
- Azurocidin
- Burn
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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