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Prostaglandins and ...
Prostaglandins and Radical Oxygen Species Are Involved in Microvascular Effects of Hyperoxia
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- Rousseau, Andreas (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Anestesiologi med intensivvård,Hälsouniversitetet,Anestesi- och operationkliniken US
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- Tesselaar, Erik (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Henricson, Joakim (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Sjöberg, Folke (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Brännskadevård,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US,Anestesi- och operationkliniken US
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(creator_code:org_t)
- 2010-02-10
- 2010
- Engelska.
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Ingår i: JOURNAL OF VASCULAR RESEARCH. - : S. Karger AG. - 1018-1172 .- 1423-0135. ; 47:5, s. 441-450
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.karger.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Hyperoxia causes vasoconstriction in most tissues, by mechanisms that are not fully understood. We investigated microvascular effects of breathing 100% oxygen in healthy volunteers, using iontophoresis to deliver acetylcholine (ACh) and sodium nitroprusside (SNP). Aspirin and vitamin C were used to test for involvement of prostaglandins and radical oxygen species. Forearm skin perfusion was measured using laser Doppler perfusion imaging. Results were analysed using dose-response modelling. The response to ACh was reduced by 30% during oxygen breathing compared to air breathing [0.98 (0.81-1.15) PU vs. 1.45 (1.30-1.60) PU, p andlt; 0.001]. ED50 values were unchanged [2.25 (1.84-2.75) vs. 2.21 (1.79-2.74), not significant]. Aspirin pre-treatment abolished the difference in response between oxygen breathing and air breathing [maximum: 1.03 (0.90-1.16) vs. 0.89 (0.77-1.01), not significant; ED50: 1.83 (1.46-2.30) vs. 1.95 (1.65-2.30), not significant]. ACh-mediated vasodilatation during 100% oxygen breathing was partially restored after pre-treatment with vitamin C. Breathing 100% oxygen did not change the microvascular response to SNP [1.45 (1.28-1.62) vs. 1.40 (1.26-1.53), not significant]. These results favour the hypothesis that hyperoxic vasoconstriction is mediated by inhibition of prostaglandin synthesis. Radical oxygen species may be involved as vitamin C, independently of aspirin, partially restored ACh-mediated vasodilatation during hyperoxia.
Nyckelord
- Acetylcholine
- Perfusion
- Hyperoxia
- Iontophoresis
- Prostaglandins
- Radical oxygen species
- Sodium nitroprusside
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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