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IL-7 mediates Ebf-1...
IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors
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- Tsapogas, Panagiotis (författare)
- Linköpings universitet,Experimentell hematologi,Hälsouniversitetet
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- Zandi, Sasan (författare)
- Linköpings universitet,Experimentell hematologi,Hälsouniversitetet
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- Åhsberg, Josefine (författare)
- Linköpings universitet,Experimentell hematologi,Hälsouniversitetet
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- Zetterblad, Jenny (författare)
- Linköpings universitet,Experimentell hematologi,Hälsouniversitetet
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- Welinder, Eva (författare)
- Lund University,Lunds universitet,Linköpings universitet,Experimentell hematologi,Hälsouniversitetet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Jönsson, Jan-Ingvar (författare)
- Linköpings universitet,Experimentell hematologi,Hälsouniversitetet
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- Månsson, Robert (författare)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine
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- Qian, Hong (författare)
- Linköpings universitet,Experimentell hematologi,Hälsouniversitetet
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- Sigvardsson, Mikael (författare)
- Linköpings universitet,Experimentell hematologi,Hälsouniversitetet
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(creator_code:org_t)
- American Society of Hematology, 2011
- 2011
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 118:5, s. 1283-1290
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- eficiencies in the IL-7 signaling pathway result in severe disruptions of lymphoid development in adult mice. To understand more about how IL-7 deficiency impacts early lymphoid development, we have investigated lineage restriction events within the common lymphoid progenitor (CLP) compartment in IL-7 knockout mice. This revealed that although IL-7 deficiency had a minor impact on the development of LY6D(-) multipotent CLPs, the formation of the lineage restricted LY6D(+) CLP population was dramatically reduced. This was reflected in a low-level transcription of B-lineage genes as well as in a loss of functional B-cell commitment. The few Ly6D(+) CLPs developed in the absence of IL-7 displayed increased lineage plasticity and low expression of Ebf-1. Absence of Ebf-1 could be linked to increased plasticity because even though Ly6D(+) cells develop in Ebf-1-deficient mice, these cells retain both natural killer and dendritic cell potential. This reveals that IL-7 is essential for normal development of Ly6D(+) CLPs and that Ebf-1 is crucial for lineage restriction in early lymphoid progenitors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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