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Curcumin Promotes A...
Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila
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- Ceasar (Berg), Ina (författare)
- Linköpings universitet,Proteinkemi,Tekniska högskolan
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- Jonsson, Maria (författare)
- Linköpings universitet,Proteinkemi,Tekniska högskolan
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- Nilsson, Peter (författare)
- Linköpings universitet,Organisk Kemi,Tekniska högskolan
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- Thor, Stefan (författare)
- Linköpings universitet,Utvecklingsbiologi,Hälsouniversitetet
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- Hammarström, Per (författare)
- Linköpings universitet,Proteinkemi,Tekniska högskolan
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(creator_code:org_t)
- 2012-02-13
- 2012
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 7:2
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The pathology of Alzheimers disease (AD) is characterized by the presence of extracellular deposits of misfolded and aggregated amyloid-beta (A beta) peptide and intraneuronal accumulation of tangles comprised of hyperphosphorylated Tau protein. For several years, the natural compound curcumin has been proposed to be a candidate for enhanced clearance of toxic A beta amyloid. In this study we have studied the potency of feeding curcumin as a drug candidate to alleviate A beta toxicity in transgenic Drosophila. The longevity as well as the locomotor activity of five different AD model genotypes, measured relative to a control line, showed up to 75% improved lifespan and activity for curcumin fed flies. In contrast to the majority of studies of curcumin effects on amyloid we did not observe any decrease in the amount of A beta deposition following curcumin treatment. Conformation-dependent spectra from p-FTAA, a luminescent conjugated oligothiophene bound to A beta deposits in different Drosophila genotypes over time, indicated accelerated pre-fibrillar to fibril conversion of A beta(1-42) in curcumin treated flies. This finding was supported by in vitro fibrillation assays of recombinant A beta(1-42). Our study shows that curcumin promotes amyloid fibril conversion by reducing the pre-fibrillar/oligomeric species of A beta, resulting in a reduced neurotoxicity in Drosophila.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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