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Overexpression of G...
Overexpression of GLUT1 in colorectal cancer is independently associated with poor prognosis
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- Shen, Yang-mei (författare)
- Linköpings universitet,Hälsouniversitetet,Onkologi
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- Arbman, Gunnar (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Kirurgi,Hälsouniversitetet,Kirurgiska kliniken i Östergötland
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- Olsson, Birgit (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Sun, Xiao-Feng (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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(creator_code:org_t)
- Wichtig Editore, 2011
- 2011
- Engelska.
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Ingår i: International Journal of Biological Markers. - : Wichtig Editore. - 0393-6155 .- 1724-6008. ; 26:3, s. 166-172
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- Background: To investigate the expression of glucose transporter 1 (GLUT1) in colorectal cancer (CRC) and its relationship to clinicopathological variables. Methods: The expression of GLUT1 in 163 primary tumors together with the corresponding normal mucosa, and 36 liver metastases was examined using real-time PCR. Results: The mean value of GLUT1 was higher in primary tumors (50.390 +/- 68.648) than in the corresponding normal mucosa (20.437 +/- 28.703, p less than 0.0001), while there was no significant difference in GLUT1 expression between CRC and liver metastasis (50.390 +/- 68.648 vs 52.277 +/- 52.482, p = 0.190). In CRCs, GLUT1 expression was higher in poorly differentiated than in well and moderately differentiated tumors (p = 0.022), and higher in stage III + IV than in stage I + II tumors (p = 0.035). The patients with high-expressed GLUT1 had a worse prognosis than those with low-expressed GLUT1 independently of gender, age, tumor site, stage and differentiation (p = 0.026, RR 2.737, 95% CI 1.126-6.651) in stage I-III CRCs. In liver metastasis, GLUT1 expression was higher in larger tumors than in smaller ones (p = 0.025). Conclusions: Overexpression of GLUT1 in stage I-III CRCs was independently associated with poor prognosis.
Nyckelord
- GLUT1; Colorectal cancer; Prognosis; Real-time PCR
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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