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Cytokine mapping in...
Cytokine mapping in cerebrospinal fluid and blood in multiple sclerosis patients without oligoclonal bands
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- Vrethem, Magnus (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken
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- Kvarnström, Maria (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Stenstam, J (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Cassel, Petra (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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- Gustafsson, M (författare)
- Linköpings universitet,Neurologi,Hälsouniversitetet
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- Landtblom, Anne-Marie (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken,Medicinska specialistkliniken
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- Ernerudh, Jan (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
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(creator_code:org_t)
- 2011-09-30
- 2012
- Engelska.
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Ingår i: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 18:5, s. 669-673
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Since there are clinical and genetic differences between MS patients with intrathecal oligoclonal bands (OCB+ ) in the cerebrospinal fluid (CSF) compared with those without (OCB-), the aim was to find out if OCB- patients showed a different pattern of cytokine immune activation compared with OCB+ patients. Methods: The study included 25 MS patients (10 OCB- and 15 OCB+ ) and 13 controls. A panel of cytokines was measured; IL-1β, IL-6, IL-8/CXCL8, IL-10, TNF and GM-CSF in serum, CSF and in supernatants from polyclonally stimulated blood mononuclear cells, where also levels of IL-12p40, IL-13, IL-15, IL-17 and IFN-γ were measured. The concentrations of soluble (s) VCAM-1 and sCD14 were measured in serum and CSF. Results: In general, there were no extensive differences in cytokine concentrations between the OCB- and OCB+ groups. Conclusion: OCB- MS patients do not seem to constitute a separate entity concerning inflammatory parameters measured as cytokine concentrations in CSF and blood.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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