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The biocompatibilit...
The biocompatibility and antibacterial properties of collagen-stabilized, photochemically prepared silver nanoparticles
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- Alarcon, Emilio I (författare)
- University of Ottawa
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- Udekwu, Klas (författare)
- Karolinska Institutet
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- Skog, Mårten (författare)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Pacioni, NataliL (författare)
- University of Ottawa
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- Stamplecoskie, Kevin G (författare)
- University of Ottawa
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- Gonzalez-Bejar, Maria (författare)
- University of Ottawa
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- Polisetti, Naresh (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Wickham, Abeni (författare)
- Linköpings universitet,Sensorvetenskap och Molekylfysik,Tekniska högskolan
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- Richter-Dahlfors, Agneta (författare)
- Karolinska Institutet
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- Griffith, May (författare)
- Linköpings universitet,Oftalmiatrik,Hälsouniversitetet
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- Scaiano, Juan C (författare)
- University of Ottawa
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(creator_code:org_t)
- Elsevier, 2012
- 2012
- Engelska.
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Ingår i: Biomaterials. - : Elsevier. - 0142-9612 .- 1878-5905. ; 33:19, s. 4947-4956
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Spherical 3.5 nm diameter silver nanoparticles (AgNP) stabilized in type I collagen (AgNP@collagen) were prepared in minutes (5-15 min) at room temperature by a photochemical method initiated by UVA irradiation of a water-soluble non-toxic benzoin. This biocomposite was examined to evaluate its biocompatibility and its anti-bacterial properties and showed remarkable properties. Thus, while keratinocytes and fibroblasts were not affected by AgNP@collagen, it was bactericidal against Bacillus megaterium and E. coli but only bacteriostatic against S. epidermidis. In particular, the bactericidal properties displayed by AgNP@collagen were proven to be due to AgNP in AgNP@collagen, rather than to released silver ions, since equimolar concentrations of Ag are about four times less active than AgNP@collagen based on total Ag content. This new biocomposite was stable over a remarkable range of NaCl, phosphate, and 2-(N-morpholino)ethanesulfonic acid concentrations and for over one month at 4 degrees C. Circular dichroism studies show that the conformation of collagen in AgNP@collagen remains intact. Finally, we have compared the properties of AgNP@collagen with a similar biocomposite prepared using alpha-poly-L-Lysine and also with citrate stabilized AgNP; neither of these materials showed comparable biocompatibility, stability, or anti-bacterial activity.
Nyckelord
- Silver nano particles
- Type-I collagen
- Poly-L-Lysine
- Cell toxicity
- Antimicrobial activity
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Alarcon, Emilio ...
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Udekwu, Klas
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Skog, Mårten
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Pacioni, NataliL
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Stamplecoskie, K ...
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Gonzalez-Bejar, ...
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visa fler...
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Polisetti, Nares ...
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Wickham, Abeni
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Richter-Dahlfors ...
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Griffith, May
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Scaiano, Juan C
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visa färre...
- Artiklar i publikationen
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Biomaterials
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet