Sökning: id:"swepub:oai:DiVA.org:liu-79903" >
Autoantibodies to l...
Autoantibodies to leucocyte antigens in hydralazine-associated nephritis
-
- Almroth, Gabriel (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Njurmedicin,Hälsouniversitetet,Njurmedicinska kliniken
-
- Eneström, S. (författare)
- Linköpings universitet,Patologi,Hälsouniversitetet
-
- Hed, J. (författare)
- Linköpings universitet,Östergötlands Läns Landsting,Transfusionsmedicin och klinisk immunologi,Hälsouniversitetet
-
visa fler...
-
- Samuelsson, I. (författare)
- Section of Nephrology, Department of Internal Medicine. Örebro Medical Centre, Örebro, Sweden
-
- Sjöström, P. (författare)
- Section of Nephrology, Department of Internal Medicine. Örebro Medical Centre, Örebro, Sweden
-
visa färre...
-
(creator_code:org_t)
- Wiley, 1992
- 1992
- Engelska.
-
Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 231:1, s. 37-42
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Clinical and laboratory findings and drug history were studied in 17 patients with suspected hydralazine-associated nephritis, five of whom only had renal disease, while twelve also had extrarenal manifestations. Renal biopsies revealed extracapillary proliferative or focal segmental proliferative glomerulonephritis in 10 patients, and tubulo-interstitial nephritis in five patients. Antinuclear antibody (ANA) was found in 16 patients, but none of the 14 patients tested had antibodies to DNA. Tests for antibodies to myeloperoxidase (anti-MPO) and antibodies to neutrophil cytoplasm antigen (ANCA) were performed by ELISA. Twelve of the 14 patients tested had anti-MPO; five of these 14 patients had ANCA, while one had borderline levels. These findings suggest that hydralazine facilitates the induction of a systemic disease with multiple autoantibody production.
Nyckelord
- ANA
- ANCA
- anti-MPO
- hydralazine
- systemic lupus erythematosus
- vasculitis
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas