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Estradiol causes do...
Estradiol causes dose-dependent increase in galanin-like immunoreactivity in both ventral and dorsal hippocampus
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- Rugarn, Olof (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Hammar, Mats (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Theodorsson, Elvar (författare)
- Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The purpose of the study was to investigate the dose- and duration effects of estradiol treatment on galanin-like immunoreactivity in ventral and dorsal rat hippocampus. Ovariectomized rats were treated three, 20 or 60 days with low or high pharmacological doses of estradiol or with carrier only. Galanin-like immunoreactivity was measured with radioimmunoassay using antiserum GalRat4 raised against rat galanin. ANOVA revealed a significant effect from dose (p<0.001) and from duration (p<0.001) of estrogen treatment, but not from region, i.e. ventral or dorsal hippocampus. With the high pharmacological dose, galanin-like immunoreactivity increased more than 10-fold in comparison with the vehicle-treated in dorsal hippocampus and about 6-fold in ventral hippocampus. The increment is most likely due to an effect in the noradrenergic galanin-expressing neurons originating in locus ceruleus. The functional interpretation of these results is dependent on the yet unknown role of galanin in their hippocampal nerve terminals.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)