In vivo determination of local skin optical properties and perfusion using a pathlength compensated spatially resolved laser Doppler flowmetry approach

• The laser Doppler flowmetry (LDF) perfusion estimate is almost linearly related to the pathlength of the detected photons, and, consequently, sensitive to the optical properties of the tissue. Therefore, we propose an in vivo pathlength and optical property estimation method, based on diffuse reflectance and Monte Carlo simulations, that minimizes the influence of optical properties on the LDF perfusion estimate. Caucasian human skin displayed a maximrun variation of -35% in the photon pathlength between individuals in similar locations, and within individuals comparing fingertip and forearm skin. The results suggest that, using the proposed method, it is possible to minimize the influence of optical properties, thus enabling intraw and inter-individual compatisons ofLDF perfusion estimates in different organs.

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MEDICINE

MEDICIN

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