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High curability via...
High curability via intensive reinduction chemotherapy and stem cell transplantation in young adults with relapsed acute lymphoblastic leukemia in Sweden 2003-2007
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- Kozlowski, Piotr, 1969- (författare)
- Hematology Section, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Åström, Maria, 1959- (författare)
- Hematology Section, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Ahlberg, Lucia (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US,Department of Hematology, University Hospital of Linköping, Linköping, Sweden
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- Bernell, Per (författare)
- Karolinska University Hospital, Stockholm, Sweden
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- Hulegardh, Erik (författare)
- Sahlgrenska University, Sweden,Department of Hematology and Coagulation, Sahlgrenska Hospital, Gothenburg, Sweden
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- Hägglund, Hans (författare)
- Uppsala universitet,Hematologi,Karolinska University Hospital, Sweden
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- Karlsson, Karin (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden
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- Markuszewska-Kuczynska, Alicja (författare)
- Umeå universitet,Onkologi,Umeå University Hospital, Sweden
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- Tomaszewska-Toporska, Beata (författare)
- Department of Hematology, Skåne University Hospital, Lund, Sweden
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- Smedmyr, Bengt (författare)
- Uppsala universitet,Hematologi,Uppsala University, Sweden
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- Hallböök, Helene (författare)
- Uppsala universitet,Hematologi,Uppsala University, Sweden
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(creator_code:org_t)
- 2012-04-17
- 2012
- Engelska.
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Ingår i: Haematologica. - : Ferrata Storti Foundation. - 0390-6078 .- 1592-8721. ; 97:9, s. 1414-1421
- Relaterad länk:
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https://doi.org/10.3...
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https://doi.org/10.3...
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background less thanbrgreater than less thanbrgreater thanA minority of patients with adult acute lymphoblastic leukemia who relapse are rescued. The aim of this population-based study was to assess the results of reinduction treatment and allogeneic stem cell transplantation in patients in second complete remission. less thanbrgreater than less thanbrgreater thanDesign and Methods less thanbrgreater than less thanbrgreater thanBetween 2003-2007, 76 adults (andlt;66 years) with relapsed acute lymphoblastic leukemia (Burkitts leukemia excluded) were prospectively reported to The Swedish Adult Acute Leukemia Registry and later evaluated. less thanbrgreater than less thanbrgreater thanResults less thanbrgreater than less thanbrgreater thanReinduction with: (i) mitoxantrone, etoposide, and cytarabine (MEA); (ii) fludarabine, cytarabine, pegylated-asparaginase plus granulocyte colony-stimulating factor (FLAG-Asp); and (iii) cytarabine, betamethasone, cyclophosphamide, daunorubicin, and vincristine (ABCDV) resulted in complete remission in 6/9 (67%), 10/16 (63%) and 9/21 (43%) of the patients, respectively. Allogeneic stem cell transplantation was performed during second complete remission in 29 patients. Multivariate analysis regarding overall survival after relapse revealed that age over 35 years at diagnosis and relapse within 18 months were negative prognostic factors. Overall survival rates at 3 and 5 years were 22% (95% CI: 13-32) and 15% (95% CI: 7-24). Of 19 patients less than 35 years at diagnosis who underwent allogeneic stem cell transplantation in second remission, ten (53%) are still alive at a median of 5.5 years (range, 4.2-8.3) after relapse, whereas all patients over 35 years old at diagnosis have died. less thanbrgreater than less thanbrgreater thanConclusions less thanbrgreater than less thanbrgreater thanAllogeneic stem cell transplantation remains the treatment of choice for young adults with relapsed acute lymphoblastic leukemia. Both (i) mitoxantrone, etoposide, and cytarabine and (ii) fludarabine, cytarabine, pegylated-asparaginase plus granulocyte colony-stimulating factor seem effective as reinduction treatments and should be further evaluated. New salvage strategies are needed, especially for patients over 35 years old at diagnosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Nyckelord
- adult acute lymphoblastic leukemia
- relapse
- salvage therapy
- allogeneic stem cell transplantation
- prognostic factors
- MEDICINE
- MEDICIN
- adult acute lymphoblastic leukemia
- relapse
- salvage therapy
- allogeneic
- stem cell transplantation
- prognostic factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kozlowski, Piotr ...
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Åström, Maria, 1 ...
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Ahlberg, Lucia
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Bernell, Per
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Hulegardh, Erik
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Hägglund, Hans
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Karlsson, Karin
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Markuszewska-Kuc ...
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Tomaszewska-Topo ...
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Smedmyr, Bengt
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Hallböök, Helene
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
- Artiklar i publikationen
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Haematologica
- Av lärosätet
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Linköpings universitet
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Örebro universitet
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Lunds universitet
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Umeå universitet
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Uppsala universitet