Disposable total internal reflection fluorescence lab-on-a-chip for medical diagnosis

• Lab-on-a-chip detection of fluorescence transduced chemical stimuli is demonstrated using fluidics and optical coupling disposable elements in a configuration compatible with distributed diagnosis.Disposable optical elements are designed to separate excitation by total internal reflection using regular glass slides as optical light guide and fluidics support, while high dynamic range image acquisition with consumer cameras complement the platform to support a broad range of responses with a same configuration. Complementary tone mapping procedures are introduced to systematically double the sensitivity for selected range intervals.Chemical sensitization to free fucose, a diagnostic marker for liver cirrhosis and several cancer forms, illustrates the platform capabilities for diagnosis targets.

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