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Bronchial Responsiv...
Bronchial Responsiveness to Dry Air Hyperventilation in Smokers May Predict Decline in Airway Status Using Indirect Methods
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- Blomstrand, Peter (författare)
- Jönköping University,HHJ. Biomedicinsk plattform
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- Ekedahl, Susanne (författare)
- Rosenlund Primary Care Unit, Jönköping, 551 85, Sweden
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- Schmekel, Birgitta (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk fysiologi,Hälsouniversitetet,Fysiologiska kliniken US,Division of Clinical Physiology, Department of Medicine and Health, Faculty of Health Sciences, Linköping University; and Department of Clinical Physiology, County Council of Östergötland, Linköping, Sweden
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Jönköping University HHJ Biomedicinsk plattform (creator_code:org_t)
- 2013-01-25
- 2013
- Engelska.
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Ingår i: Lung. - : Springer Verlag (Germany). - 0341-2040 .- 1432-1750. ; 191:2, s. 183-190
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Disabling respiratory symptoms and rapid decline of lung function may occur in susceptible tobacco smokers. Bronchial hyperresponsiveness (BHR) elicited by direct challenge methods predicts worse lung function outcomes. The aim of this study was to evaluate whether BHR to isocapnic hyperventilation of dry air (IHDA) was associated with rapid deterioration in airway status and respiratory symptoms. less thanbrgreater than less thanbrgreater thanOne hundred twenty-eight smokers and 26 age- and sex-matched healthy individuals with no history of smoking were investigated. All subjects completed a questionnaire. Spirometry and impulse oscillometry (IOS) measurements were recorded before and after 4 min of IHDA. The tests were repeated after 3 years in 102 smokers and 11 controls. less thanbrgreater than less thanbrgreater thanEighty-five smokers (66 %) responded to the challenge with a a parts per thousand yen2.4-Hz increase in resonant frequency (F (res)), the cutoff limit defining BHR, as recorded by IOS. They had higher F (res) at baseline compared to nonresponding smokers [12.8 +/- A 3.2 vs. 11.5 +/- A 3.4 Hz (p andlt; 0.05)] and lower FEV1 [83 +/- A 13 vs. 89 +/- A 13 % predicted (p andlt; 0.05)]. Multivariable logistic regression analysis indicated that wheezing (odds ratio = 3.7, p andlt; 0.01) and coughing (odds ratio = 8.1, p andlt; 0.05) were significantly associated with hyperresponsiveness. An increase in F (res) was recorded after 3 years in responding smokers but not in nonresponders or controls. The difference remained when subjects with COPD were excluded. less thanbrgreater than less thanbrgreater thanThe proportion of hyperresponsive smokers was unexpectedly high and there was a close association between wheezing and coughing and BHR. Only BHR could discriminate smokers with rapid deterioration of airway status from others.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Bronchial hyperresponsiveness
- Impulse oscillometry
- Isocapnic hyperventilation of dry air
- Resonant frequency
- Tobacco smoke
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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