Infliximab as rescue therapy in hospitalised patients with steroid-refractory acute ulcerative colitis: a long-term follow-up of 211 Swedish patients

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Infliximab as rescue therapy in hospitalised patients with steroid-refractory acute ulcerative colitis: a long-term follow-up of 211 Swedish patients

Sjöberg, Mats (författare): Örebro universitet,Institutionen för hälsovetenskap och medicin,Skaraborgs Hospital, Lidköping, Sweden

Magnuson, A (författare): Clinical Epidemiology and Biostatistics Unit, Örebro University Hospital, Örebro, Sweden

Bjork, J (författare): Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, Sweden

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Benoni, Cecilia (författare): Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden

Almer, Sven (författare): Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Magtarmmedicinska kliniken,Division of Gastroenterology and Hepatology, Faculty of Health Sciences, Linköping University, Linköping, Sweden

Friis-Liby, I (författare): Division of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

Hertervig, Erik (författare): Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Gastroenterology, Skåne University Hospital, Lund, Sweden

Olsson, M (författare): Department of Medicine, NÄL Hospital, Trollhättan, Sweden

Karlen, P (författare): Karolinska Institutet,Soder Sjukhuset, Sweden,Division of Gastroenterology, Department of Medicine, South Hospital, Stockholm, Sweden

Eriksson, A (författare): Ostra Hospital, Sweden,Division of Gastroenterology, Department of Internal Medicine and Geriatrics, Sahlgrenska University Hospital, Gothenburg, Sweden

Midhagen, Gunnar (författare): Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Skaraborgs Hospital, Lidköping, Sweden

Carlson, Marie (författare): Uppsala universitet,Gastroenterologi/hepatologi

Lapidus, A (författare): Department of Gastroenterology, Ersta Hospital, Stockholm, Sweden

Halfvarson, Jonas (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden

Tysk, Curt (författare): Örebro universitet,Institutionen för hälsovetenskap och medicin,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden

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(creator_code:org_t)

2013-06-25
2013
Engelska.
Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley-Blackwell. - 0269-2813 .- 1365-2036. ; 38:4, s. 377-387

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BackgroundRescue therapy with infliximab (IFX) has been proven effective in a steroid-refractory attack of ulcerative colitis (UC). The long-term efficacy is not well described. less thanbrgreater than less thanbrgreater thanAimTo present a retrospective study of IFX as rescue therapy in UC. Primary end points were colectomy-free survival at 3 and 12months. less thanbrgreater than less thanbrgreater thanMethodsIn this multicentre study, 211 adult patients hospitalised between 1999 and 2010 received IFX 5mg/kg as rescue therapy due to a steroid-refractory, moderate-to-severe attack of UC. Exclusion criteria were duration of current flare for andgt;12weeks, corticosteroid treatment for andgt;8weeks before hospitalisation, previous IFX therapy or Crohns disease. less thanbrgreater than less thanbrgreater thanResultsProbability of colectomy-free survival at 3months was 0.71 (95% CI, 0.64-0.77), at 12months 0.64 (95% CI, 0.57-0.70), at 3years 0.59 (95% CI, 0.52-0.66) and at 5years 0.53 (95% CI, 0.44-0.61). Steroid-free, clinical remission was achieved in 105/211 (50%) and 112/209 (54%) patients at 3 and 12months respectively. Of 75 colectomies during the first year, 48 (64%) were carried out during the first 14days, 13 (17%) on days 15-90 and 14 (19%) between 3 and 12months. There were three (1.4%) deaths during the first 3months. less thanbrgreater than less thanbrgreater thanConclusionsInfliximab is an effective rescue treatment, both short- and long-term, in a steroid-refractory attack of UC. Most IFX failures underwent surgery during the first 14days, which calls for studies on how to optimise induction treatment with IFX. Serious complications, including mortality, were rare.

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Av författaren/redakt...: Sjöberg, Mats; Magnuson, A; Bjork, J; Benoni, Cecilia; Almer, Sven; Friis-Liby, I; visa fler...; Hertervig, Erik; Olsson, M; Karlen, P; Eriksson, A; Midhagen, Gunnar; Carlson, Marie; Lapidus, A; Halfvarson, Jona ...; Tysk, Curt; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

Artiklar i publikationen: Alimentary Pharm ...

Av lärosätet: Linköpings universitet; Lunds universitet; Karolinska Institutet; Örebro universitet; Uppsala universitet

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Infliximab as rescue therapy in hospitalised patients with steroid-refractory acute ulcerative colitis: a long-term follow-up of 211 Swedish patients

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