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Evidence for Age-Dependent in Vivo Conformational Rearrangement within A beta Amyloid Deposits
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- Nyström, Sofie (author)
- Linköpings universitet,Kemi,Tekniska högskolan
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- Psonka-Antonczyk, Katarzyna M. (author)
- Norwegian University of Science and Technology, Norway
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- Ellingsen, Pal Gunnar (author)
- Norwegian University of Science and Technology, Norway
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- (creator_code:org_t)
- 2013-03-29
- 2013
- English.
- In: ACS Chemical Biology. - : American Chemical Society. - 1554-8929 .- 1554-8937. ; 8:6, s. 1128-1133
- Journal article (peer-reviewed)
Abstract
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- Deposition of aggregated A beta peptide in the brain is one of the major hallmarks of Alzheimers disease. Using a combination of two structurally different, but related, hypersensitive fluorescent amyloid markers, LCOs, reporting on separate ultrastructural elements, we show that conformational rearrangement occurs within A beta plaques of transgenic mouse models as the animals age. This important mechanistic insight should aid the design and evaluation of experiments currently using plaque load as readout.
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- TECHNOLOGY
- TEKNIKVETENSKAP
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- ref (subject category)
- art (subject category)
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