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Generation of norma...
Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells
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- Chen, J. (författare)
- Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Boston, Massachusetts, USA
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- Stewart, V. (författare)
- Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Boston, Massachusetts, USA
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- Spyrou, Giannis (författare)
- Department of Biosciences at Novum, Center for Biotechnology, Karolinska Institutet, Huddinge, Sweden
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- Hilberg, F. (författare)
- Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Boston, Massachusetts, USA
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- Wagner, E. F. (författare)
- Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Boston, Massachusetts, USA
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- Alt, F. W. (författare)
- Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Boston, Massachusetts, USA
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(creator_code:org_t)
- Cell Press, 1994
- 1994
- Engelska.
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Ingår i: Immunity. - : Cell Press. - 1074-7613 .- 1097-4180. ; 1:1, s. 65-72
- Relaterad länk:
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http://www.sciencedi...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantial numbers of mature T and B lymphocytes in the periphery. Stimulation of c-jun-/- B cells resulted in normal levels of proliferation and immunoglobulin secretion. Likewise, stimulation of c-jun-/- T cells resulted in essentially normal levels of IL-2R alpha expression, IL-2 secretion, and proliferation. We further showed that the relatively normal activation responses of the c-jun-/- T cells probably results from the fact that other members of the Jun family contribute to the bulk of the activator protein-1 (AP-1) complexes in normal T cells and, as a result, AP-1 complexes are found at relatively normal levels in c-jun-/- T cells.
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