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Sputter Deposition ...
Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility
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- Sharifi, Sina (författare)
- Massachusetts Eye & Ear, USA;Harvard Med Sch, USA
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- Islam, Mohammad Mirazul (författare)
- Massachusetts Eye & Ear, USA;Harvard Med Sch, USA
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- Sharifi, Hannah (författare)
- Massachusetts Eye & Ear, USA;Harvard Med Sch, USA
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- Islam, Rakibul (författare)
- Univ Oslo, Norway
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- Nilsson, Per H., 1980- (författare)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Avancerade material,Univ Oslo, Norway,Linnaeus Ctr Biomat Chem, BMC;HoRB
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- Dohlman, Claes H. (författare)
- Massachusetts Eye & Ear, USA;Harvard Med Sch, USA
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- Mollnes, Tom Eirik (författare)
- Univ Oslo, Norway;Nordland Hosp, Norway;Univ Tromso, Norway;Norwegian Univ Sci & Technol, Norway
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- Paschalis, Eleftherios, I (författare)
- Massachusetts Eye & Ear, USA;Harvard Med Sch, USA
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- Chodosh, James (författare)
- Massachusetts Eye & Ear, USA;Harvard Med Sch, USA
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(creator_code:org_t)
- Association for Research in Vision and Ophthalmology, 2020
- 2020
- Engelska.
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Ingår i: Translational Vision Science & Technology. - : Association for Research in Vision and Ophthalmology. - 2164-2591. ; 9:13, s. 1-14
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: To evaluate titanium (Ti) sputtering of the poly(methyl methacrylate) (PMMA) stem of the Boston Keratoprosthesis (BK) as a method to enhance interfacial adhesion between the PMMA and the recipient corneal tissue. Methods: PMMA specimens were plasma treated with Ar/O-2 and coated with Ti using a DC magnetron sputtering instrument. The topography and hydrophilicity of the surfaces were characterized using atomic force microscopy and a water contact angle instrument, respectively. Scratch hardness and adhesion of the Ti film were measured using a mechanical tester. Biocompatibility assessments were performed using cultured human corneal fibroblasts and whole blood ex vivo. The optical quality of the Ti sputtered BK was evaluated using a custom-made optical bench. Results: By contact angle studies, the Ti coating improved PMMA hydrophilicity to match that of medical-grade Ti (Ti-6Al-4V-ELI). Ti sputtering of contact surfaces resulted in a plate-like morphology with increased surface roughness, without impacting the transparency of the BK optical component. Scratch testing indicated that the mechanical behavior of the Ti coating was similar to that of casted Ti, and the coating was stable in pull-off adhesion testing. Sputtered Ti film was highly biocompatible based on tests of cell viability, adhesion, proliferation, differentiation, collagen deposition, and keratocan expression, the properties of which exceeded those of uncoated PMMA and did not induce increased complement activation. Conclusions: Titanium coating of the BK stem generated a mechanically and biologically favorable interface, which may help to enhance corneal stromal adhesion and biocompatibility. Translational Relevance: Improving the biocompatibility of the BK PMMA stem may improve long-term outcomes of implantation.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Nyckelord
- poly(methyl methacrylate) (PMMA)
- titanium sputtered coating
- Boston Keratoprosthesis
- artificial cornea
- biocompatibility
- Biokemi
- Biochemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sharifi, Sina
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Islam, Mohammad ...
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Sharifi, Hannah
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Islam, Rakibul
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Nilsson, Per H., ...
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Dohlman, Claes H ...
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visa fler...
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Mollnes, Tom Eir ...
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Paschalis, Eleft ...
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Chodosh, James
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- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Medicinteknik
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och Medicinsk materi ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Materialkemi
- Artiklar i publikationen
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Translational Vi ...
- Av lärosätet
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Linnéuniversitetet