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Complement as drive...
Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis
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- Mannes, Marco (författare)
- Univ Hosp Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany.
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- Schmidt, Christoph Q. (författare)
- Ulm Univ, Inst Pharmacol Nat Prod & Clin Pharmacol, Ulm, Germany.
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- Nilsson, Bo (författare)
- Uppsala universitet,Klinisk immunologi
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- Nilsson Ekdahl, Kristina (författare)
- Uppsala universitet,Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Uppsala University, Sweden,Linnaeus Ctr Biomat Chem, BMC,Klinisk immunologi,Linnaeus Univ, Linnaeus Ctr Biomat Chem, Kalmar, Sweden.
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- Huber-Lang, Markus (författare)
- Univ Hosp Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany.
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Univ Hosp Ulm, Inst Clin & Expt Trauma Immunol, Helmholtzstr 8-2, D-89081 Ulm, Germany Ulm Univ, Inst Pharmacol Nat Prod & Clin Pharmacol, Ulm, Germany. (creator_code:org_t)
- 2021-06-30
- 2021
- Engelska.
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Ingår i: Seminars in Immunopathology. - : Springer. - 1863-2297 .- 1863-2300. ; 43, s. 773-788
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Complement is one of the most ancient defense systems. It gets strongly activated immediately after acute injuries like trauma, burn, or sepsis and helps to initiate regeneration. However, uncontrolled complement activation contributes to disease progression instead of supporting healing. Such effects are perceptible not only at the site of injury but also systemically, leading to systemic activation of other intravascular cascade systems eventually causing dysfunction of several vital organs. Understanding the complement pathomechanism and its interplay with other systems is a strict requirement for exploring novel therapeutic intervention routes. Ex vivo models exploring the cross-talk with other systems are rather limited, which complicates the determination of the exact pathophysiological roles that complement has in trauma, burn, and sepsis. Literature reporting on these three conditions is often controversial regarding the importance, distribution, and temporal occurrence of complement activation products further hampering the deduction of defined pathophysiological pathways driven by complement. Nevertheless, many in vitro experiments and animal models have shown beneficial effects of complement inhibition at different levels of the cascade. In the future, not only inhibition but also a complement reconstitution therapy should be considered in prospective studies to expedite how meaningful complement-targeted interventions need to be tailored to prevent complement augmented multi-organ failure after trauma, burn, and sepsis. This review summarizes clinically relevant studies investigating the role of complement in the acute diseases trauma, burn, and sepsis with important implications for clinical translation.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Trauma
- Burn
- Sepsis
- Complement activation
- Thromboinflammation
- Systemic inflammation
- Clinical translation
- Immunologi
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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