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Clinical and psycho...
Clinical and psychological factors in coronary heart disease patients with statin associated muscle side-effects
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- Peersen, Kari (författare)
- Vestfold Hospital Trust, Norway;University of Oslo, Norway
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- Munkhaugen, John (författare)
- University of Oslo, Norway;Drammen Hospital, Norway
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- Sverre, Elise (författare)
- University of Oslo, Norway;Drammen Hospital, Norway
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- Kristiansen, Oscar (författare)
- Drammen Hospital, Norway
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- Fagerland, Morten (författare)
- Oslo University Hospital, Norway
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- Vethe, Nils Tore (författare)
- Oslo University Hospital, Norway
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- Perk, Joep, 1945- (författare)
- Linnéuniversitetet,Institutionen för hälso- och vårdvetenskap (HV)
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- Husebye, Einar (författare)
- Drammen Hospital, Norway
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- Dammen, Toril (författare)
- University of Oslo, Norway
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(creator_code:org_t)
- 2021-12-16
- 2021
- Engelska.
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Ingår i: BMC Cardiovascular Disorders. - : BioMed Central. - 1471-2261 .- 1471-2261. ; 21:1
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundTo compare clinical and psychological factors among patients with self-perceived statin-associated muscle symptoms (SAMS), confirmed SAMS, and refuted SAMS in coronary heart disease patients (CHD).MethodsData were obtained from a cross-sectional study of 1100 CHD outpatients and a study of 71 CHD outpatients attending a randomized, double-blinded, placebo-controlled, crossover study to test effects of atorvastatin 40 mg/day on muscle symptom intensity. Clinical and psychosocial factors were compared between patients with and without SAMS in the cross-sectional study, and between patients with confirmed SAMS and refuted SAMS in the randomized study.ResultsBilateral, symmetric muscle symptoms in the lower extremities during statin treatment were more prevalent in patients with confirmed SAMS compared to patients with refuted SAMS (75% vs. 41%, p = 0.01) in the randomized study. No significant differences in psychological factors (anxiety, depression, worry, insomnia, type D personality characteristics) were detected between patients with and without self-perceived SAMS in the cross-sectional study, or between patients with confirmed SAMS and refuted SAMS, in the randomized study.ConclusionsPatients with confirmed SAMS more often present with bilateral lower muscle symptoms compared to those with refuted SAMS. Psychological factors were not associated with self-perceived SAMS or confirmed SAMS. A careful pain history and a search for alternative causes of muscle symptoms are likely to promote communication in patients with SAMS, and may reduce the risk for statin discontinuation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Nyckelord
- Statin-associated muscle symptoms
- Coronary heart disease
- Psychological factors
- Beliefs in medicine
- Atorvastatin
- Crossover trial
- Placebo-controlled
- Omvårdnad
- Nursing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Peersen, Kari
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Munkhaugen, John
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Sverre, Elise
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Kristiansen, Osc ...
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Fagerland, Morte ...
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Vethe, Nils Tore
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visa fler...
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Perk, Joep, 1945 ...
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Husebye, Einar
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Dammen, Toril
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Omvårdnad
- Artiklar i publikationen
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BMC Cardiovascul ...
- Av lärosätet
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Linnéuniversitetet