Sökning: id:"swepub:oai:DiVA.org:lnu-1727" >
Phospholipase C fro...
Phospholipase C from Clostridium perfringens stimulates formation of platelet-activating factor (PAF-acether) in cultured intestinal epithelial cells (INT 407)
-
- Gustafson-Svärd, Christina (författare)
- Clinical Research Center, Linköping University
-
Kald, B (författare)
-
Sjödahl, R (författare)
-
visa fler...
-
Tagesson, C (författare)
-
visa färre...
-
(creator_code:org_t)
- 2009-07-08
- 1991
- Engelska.
-
Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 26:10, s. 1000-1006
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- This study demonstrates the ability of phospholipase C from Clostridium perfringens to stimulate the generation of platelet-activating factor (PAF-acether) in cultured intestinal epithelial cells (INT 407). Cells were exposed to phospholipase C for up to 60 min, and the content of PAF-acether within the cells and in the extracellular medium was determined. Phospholipase C caused a time-dependent formation of PAF-acether within the cells and also release of PAF-acether to the medium. In contrast, phospholipase C did not affect the cellular acetylhydrolase activity or the ability of the cells to metabolize extracellularly added C-14-PAF-acether. These findings suggest the possibility that intestinal epithelial cells, when stimulated with a naturally occurring intestinal bacterial toxin, generate and release PAF-acether. The possibility that this might contribute to the pathophysiology of inflammatory bowel disease is discussed.
Nyckelord
- MEDICINE
- MEDICIN
- Biomedicinsk vetenskap
- Biomedical Sciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas