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Enteroviral Central...
Enteroviral Central Nervous System Infections in Children of the Region of Monastir, Tunisia : Diagnosis, Laboratory Findings of Cerebrospinal Fluid and Clinical Manifestations
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EL Hiar, Raida (författare)
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Haddad, Samir (författare)
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Jaidane, Hela (författare)
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Hober, Didier (författare)
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Ben M'hadheb-Gharbi, Manel (författare)
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- Gullberg, Maria (författare)
- Linnéuniversitetet,Institutionen för naturvetenskap, NV
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Neji-Guediche, Mohamed (författare)
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- Lindberg, A. Michael (författare)
- Linnéuniversitetet,Institutionen för naturvetenskap, NV
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Gharbi, Jawhar (författare)
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Aouni, Mahjoub (författare)
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(creator_code:org_t)
- 2012-09-04
- 2012
- Engelska.
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Ingår i: Indian Journal of Virology. - : Springer Science and Business Media LLC. - 0970-2822 .- 0974-0120. ; 23:3, s. 294-302
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Human enteroviruses (HEV) are one of the major causes of central nervous system (CNS) infections in pediatrics. A prospective study was conducted to assess the epidemiological, clinical, and laboratory characteristics of enterovirus (EV) infections of the CNS in children under 15-years-old, suspected of having viral CNS infections and admitted to the Pediatric Department of Monastir University Hospital, Tunisia. Enteroviral RNA was detected by 5' NCR nested RT-PCR assay in 33 % (20 out of 60) of cerebrospinal fluid specimens, whereas only six samples (10 %) were EV positive in cell culture. EV-positive patients were clustered according to their clinical manifestations, predominantly diagnosed as aseptic meningitis (65 %) and meningoencephalitis (20 %). Fever, headache, vomiting, and neck stiffness were the most pronounced symptoms. Pleocytosis with the predominance of lymphocytes was observed in 60 % of EV positive specimens. Although patients suffering from EV infections were encountered throughout the year, most occurred during spring and summer months. Using VP1-2A nested RT-PCR and sequence analysis, three of the 20 positive HEV were identified as Echovirus (E)-9. This is the first report of a cluster of aseptic meningitis cases caused by E-9 in Monastir.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Enterovirus
- Cerebrospinal fluid
- Children
- Molecular typing
- Epidemiology
- Virologi
- Virology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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