Tyck till om SwePub Sök
här!
Sökning: id:"swepub:oai:DiVA.org:lnu-60940" >
The alternative com...
The alternative complement pathway is dysregulated in patients with chronic heart failure
-
- Shahini, Negar (författare)
- Oslo University Hospital, Norway;University of Oslo, Norway
-
- Michelsen, Annika E (författare)
- Oslo University Hospital, Norway;University of Oslo, Norway
-
- Nilsson, Per H. (författare)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),University of Oslo, Norway;Oslo University Hospital, Norway,Linnaeus Ctr Biomat Chem, BMC;HoRB
-
visa fler...
-
- Ekholt, Karin (författare)
- University of Oslo, Norway
-
- Gullestad, Lars (författare)
- University of Oslo, Norway;Oslo University Hospital, Norway
-
- Broch, Kaspar (författare)
- Oslo University Hospital, Norway
-
- Dahl, Christen P. (författare)
- Oslo University Hospital, Norway
-
- Aukrust, Pål (författare)
- Oslo University Hospital, Norway;University of Oslo, Norway
-
- Ueland, Thor (författare)
- Oslo University Hospital, Norway;University of Oslo, Norway
-
- Mollnes, Tom Eirik (författare)
- University of Oslo, Norway;Oslo University Hospital, Norway;University of Tromsø, Norway;Norwegian University of Science and Technology, Norway
-
- Yndestad, Arne (författare)
- Oslo University Hospital, Norway;University of Oslo, Norway
-
- Louwe, Mieke C. (författare)
- Oslo University Hospital, Norway;University of Oslo, Norway
-
visa färre...
-
(creator_code:org_t)
- 2017-02-14
- 2017
- Engelska.
-
Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7, s. 1-10
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://www.nature.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement factor D and the alternative pathway inhibitor factor H. These components and the activation product, terminal complement complex (TCC), were measured in plasma from 188 HF patients and 67 age- and sex- matched healthy controls by enzyme immunoassay. Our main findings were: (i) Compared to controls, patients with HF had significantly increased levels of factor D and TCC, and decreased levels of properdin, particularly patients with advanced clinical disorder (i.e., NYHA functional class IV), (ii) Levels of factor D and properdin in HF patients were correlated with measures of systemic inflammation (i.e., C-reactive protein), neurohormonal deterioration (i.e., Nt-proBNP), cardiac function, and deteriorated diastolic function, (iii) Low levels of factor H and properdin were associated with adverse outcome in univariate analysis and for factor H, this was also seen in an adjusted model. Our results indicate that dysregulation of circulating components of the alternative pathway explain the increased degree of complement activation and is related to disease severity in HF patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Biomedicinsk vetenskap
- Biomedical Sciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Shahini, Negar
-
Michelsen, Annik ...
-
Nilsson, Per H.
-
Ekholt, Karin
-
Gullestad, Lars
-
Broch, Kaspar
-
visa fler...
-
Dahl, Christen P ...
-
Aukrust, Pål
-
Ueland, Thor
-
Mollnes, Tom Eir ...
-
Yndestad, Arne
-
Louwe, Mieke C.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Scientific Repor ...
- Av lärosätet
-
Linnéuniversitetet