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Contact (kallikrein...
Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles
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- Nilsson Ekdahl, Kristina (author)
- Uppsala universitet,Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Uppsala University, Sweden,Linnaeus Ctr Biomat Chem, BMC,Klinisk immunologi
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- Davoodpour, Padideh (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Ekstrand-Hammarström, Barbro (author)
- Division of CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden
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- Fromell, Karin (author)
- Uppsala universitet,Klinisk immunologi
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- Hamad, Osama A., 1978- (author)
- Uppsala universitet,Klinisk immunologi
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- Hong, Jaan (author)
- Uppsala universitet,Klinisk immunologi
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- Bucht, Anders (author)
- Umeå universitet,Avdelningen för medicin,Division of CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden;Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden,Swedish Defence Research Agency, Sweden;Umeå University, Sweden
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- Mohlin, Camilla, 1972- (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC,Linnæus Centre for Biomaterials Chemistry, Linnæus University, Kalmar, Sweden
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- Seisenbaeva, Gulaim (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Department of Chemistry and Biotechnology, BioCenter, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden
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- Kessler, Vadim (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Department of Chemistry and Biotechnology, BioCenter, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden
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- Nilsson, Bo (author)
- Uppsala universitet,Klinisk immunologi
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(creator_code:org_t)
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- Elsevier, 2018
- 2018
- English.
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In: Nanomedicine. - : Elsevier. - 1549-9634 .- 1549-9642. ; 14:3, s. 735-744
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://res.slu.se/i...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Iron-oxide nanoparticles (NPs) generated by environmental events are likely to represent health problems. α-Fe2O3 NPs were synthesized, characterized and tested in a model for toxicity utilizing human whole blood without added anticoagulant. MALDI-TOF of the corona was performed and activation markers for plasma cascade systems (complement, contact and coagulation systems), platelet consumption and release of growth factors, MPO, and chemokine/cytokines from blood cells were analyzed. The coronas formed on the pristine α-Fe2O3 NPs contained contact system proteins and they induced massive activation of the contact (kinin/kallikrein) system, as well as thrombin generation, platelet activation, and release of two pro-angiogeneic growth factors: platelet-derived growth factor and vascular endothelial growth factor, whereas complement activation was unaffected. The α-Fe2O3 NPs exhibited a noticeable toxicity, with kinin/kallikreinactivation, which may be associated with hypotension and long-term angiogenesis in vivo, with implications for cancer, arteriosclerosis and pulmonary disease.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Keyword
- Contact/kallikrein system
- Innate immunity
- α-Fe(2)O(3) NPs
- Immunologi
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nilsson Ekdahl, ...
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Davoodpour, Padi ...
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Ekstrand-Hammars ...
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Fromell, Karin
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Hamad, Osama A., ...
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Hong, Jaan
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Bucht, Anders
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Mohlin, Camilla, ...
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Seisenbaeva, Gul ...
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Kessler, Vadim
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Nilsson, Bo
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Nano technology
- Articles in the publication
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Nanomedicine
- By the university
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Linnaeus University
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Umeå University
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Swedish University of Agricultural Sciences
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Uppsala University