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Saffold virus infec...
Saffold virus infection in elderly people with acute gastroenteritis in Sweden
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- Vandesande, Helena (författare)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Univ, Sweden
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- Edman, Kjell (författare)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Univ, Sweden
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- Rondahl, Elin (författare)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten
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- Falkeborn, Tina (författare)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Klinisk mikrobiologi
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- Serrander, Lena (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk mikrobiologi
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- Lindberg, A. Michael, 1958- (författare)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Univ, Sweden
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(creator_code:org_t)
- 2020-10-30
- 2021
- Engelska.
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Ingår i: Journal of Medical Virology. - : John Wiley & Sons. - 0146-6615 .- 1096-9071. ; 93:6, s. 3980-3984
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Viral gastroenteritis is a major source of morbidity and mortality, predominantly caused by so-called NOROAD viruses (norovirus, rotavirus, and adenovirus). In approximately one third of all cases, however, the exact etiology is unknown. The in 2007 discovered human cardiovirus Saffold virus (SAFV) may prove to be a plausible candidate to explain this diagnostic gap. This virus, a member of the Picornaviridae family which is closely related to the murine viruses Theiler's murine encephalomyelitis virus and Theravirus, is a widespread pathogen and causes infection early in life. Screening of 238 fecal or vomitus samples obtained from NOROAD-negative, elderly patients with acute gastroenteritis at the University Hospital of Linköping showed that SAFV is present in low abundance (4.6%). Phylogenetic analysis of the VP1 gene revealed a Swedish isolate belonging to the highly common and in Europe widespread SAFV-3 genotype. This genotype is also related to previously reported Asian strains. This study describes the first molecular typing of a Swedish SAFV isolate and is the first report to document the circulation of SAFV among elderly people. The pathogenicity of SAFV is, as of yet, still under debate; further studies are necessary to determine its role in the development of disease.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- cardiovirus
- gastroenteritis
- Saffold virus
- Sweden
- Virology
- Virologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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