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Dendrimer Induced B...
Dendrimer Induced Bilayer Disintegration of Hybrid Vesicles
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- Guha, Pritam (författare)
- Department of Chemistry, University of North Bengal, Darjeeling 734 013, West Bengal, India; Department for Biomaterials Research, Polymer Institute, Slovak Academy of Sciences, 845 41 Bratislava, Slovakia
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- Roy, Biplab (författare)
- Luleå tekniska universitet,Kemiteknik,Department of Chemistry, University of North Bengal, Darjeeling 734 013, West Bengal, India
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- Nahak, Prasant (författare)
- Department of Chemistry, University of North Bengal, Darjeeling 734 013, West Bengal, India
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- Karmakar, Gourab (författare)
- Department of Chemistry, University of North Bengal, Darjeeling 734 013, West Bengal, India
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- Karak, Atanu (författare)
- Department of Chemistry, Vidyasagar University, Midnapore 721102, West Bengal, India
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- Bykov, Alexey G. (författare)
- Department of Colloid Chemistry, St. Petersburg State University, Universitetskii pr. 26, 198504 St. Petersburg, Russia
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- Akentiev, Alexander B. (författare)
- Department of Colloid Chemistry, St. Petersburg State University, Universitetskii pr. 26, 198504 St. Petersburg, Russia
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- Noskov, Boris A. (författare)
- Department of Colloid Chemistry, St. Petersburg State University, Universitetskii pr. 26, 198504 St. Petersburg, Russia
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- Dutta, Kunal (författare)
- Department of Human Physiology, Vidyasagar University, Midnapore 721102, West Bengal, India
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- Ghosh, Chandradipa (författare)
- Department of Human Physiology, Vidyasagar University, Midnapore 721102, West Bengal, India
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- Panda, Amiya K. (författare)
- Department of Chemistry, Vidyasagar University, Midnapore 721102, West Bengal, India
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(creator_code:org_t)
- Japan Oil Chemists' Society, 2024
- 2024
- Engelska.
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Ingår i: Journal of Oleo Science. - : Japan Oil Chemists' Society. - 1345-8957 .- 1347-3352. ; 73:4, s. 547-562
- Relaterad länk:
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https://doi.org/10.5...
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https://ltu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- Physicochemical investigations on the inclusion of anionic polyamidoaminesuccinamic acid dendrimer, generation 5 (PAMAM-SA, G5) with positively charged hybrid vesicles (HCV), prepared using soylecithin, ion pair amphiphile (IPA), cholesterol and dihexadecyldimethylammonium bromide, were investigated by dynamic light scattering, transmission electron/atomic force microscopy (TEM/AFM), differential scanning calorimetry, fluorescence spectroscopy and surface pressure-time isotherm studies. Adsorption of dendrimer onto vesicle surface and subsequent bilayer disruption strongly depends on the bilayer composition and dendrimer concentration. Change in the zeta potential value with increasing dendrimer concentration suggests the dendrimer-vesicle interaction to be electrostatic in nature. AFM studies also confirm the adsorption of dendrimer as well as hole formation in the bilayer. Impact of the inclusion of dendrimer into the bilayer were further investigated through differential scanning calorimetry by monitoring the chain melting temperature and enthalpy of the chain melting processes. Dendrimer at low concentration does not alter bilayer integrity, while hole formations are noted at higher dendrimer concentration. Fluorescence anisotropy studies confirm the adsorption and subsequent bilayer disruption due to dendrimer inclusion. Dendrimer induced vesicle disintegration kinetics conclusively illustrate the transformation of cationic bilayer to monolayer and thereby exposing the role of IPA. In vitro cytotoxicity studies on PAMAM-SA, G5 and HCVs mixtures against human breast cancer cell line suggest that dendrimer-liposome aggregates (dendriosomes) exhibit substantial anticancer activities with insignificant side effects. It is expected that the dendriosomes may have application to host and deliver anticancer drug in the field of targeted drug delivery.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- hybrid cationic vesicles
- dendrimer
- monolayer adsorption kinetics
- AFM
- cytotoxicity
- Chemistry of Interfaces
- Gränsytors kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Guha, Pritam
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Roy, Biplab
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Nahak, Prasant
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Karmakar, Gourab
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Karak, Atanu
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Bykov, Alexey G.
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Akentiev, Alexan ...
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Noskov, Boris A.
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Dutta, Kunal
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Ghosh, Chandradi ...
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Panda, Amiya K.
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Fysikalisk kemi
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Journal of Oleo ...
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