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Utility of Hansen s...
Utility of Hansen solubility parameters in the cocrystal screening
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- Mohammad, Mohammad Amin (author)
- Damascus University, Department of Pharmaceutics and Pharmaceutical Technology, Facuöty of Pharmacology
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- Alhalaweh, Amjad (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Bashimam, Mais (author)
- Damascus University, Department of Pharmaceutics and Pharmaceutical Technology, Facuöty of Pharmacology
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- Al-Mardini, Mhd Amer (author)
- Damascus University, Department of Pharmaceutics and Pharmaceutical Technology, Facuöty of Pharmacology
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- Velaga, Sitaram (author)
- Luleå tekniska universitet,Medicinsk vetenskap
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Journal of Pharmacy and Pharmacology (JPP). - 0022-3573 .- 2042-7158. ; 62:10 - Spec issue, s. 1360-1362
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The objective of this study was to test if the miscibility between drug and coformer, as predicted by solubility parameters, can be used as a tool in the cocrystal research. Hansen Solubility Parameters (HSPs) of a model drug, indomethacin and thirty coformers were calculated according to the group contribution method. The distances in HSPs between indomethacin and each cocrystal former were then calculated using three validated miscibility tools. Twenty coformers were predicted and confirmed to be miscible with the drug. Interestingly, all cocrystals forming systems were miscible. Two new cocrystal systems were discovered through this approach. Therefore, the utility of the solubility parameters approach can enhance the effi ciency of cocrystal screening.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Keyword
- Health Science
- Hälsovetenskap
Publication and Content Type
- vet (subject category)
- art (subject category)
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