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Preparation of a no...
Preparation of a novel lipid-core micelle using a low-energy emulsification method
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- Fritz, Hans F. (författare)
- Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile
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- Ortiz, Andrea C. (författare)
- Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile
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- Velaga, Sitaram (författare)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Morales, Javier O. (författare)
- Luleå tekniska universitet,Medicinsk vetenskap,Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile
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(creator_code:org_t)
- 2018-04-16
- 2018
- Engelska.
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Ingår i: Drug Delivery and Translational Research. - : Springer. - 2190-393X .- 2190-3948. ; 8:6, s. 1807-1814
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsulate a poorly water-soluble drug, nifedipine (NFD), by hot-melt emulsification, a low-energy method. LCMs are self-assembling colloidal particles composed of a hydrophobic core and a hydrophilic shell. Hybrid materials, such as Gelucire 44/14, are thus excellent candidates for their preparation. We characterized the obtained nanocarriers for their colloidal properties, drug loading and encapsulation efficiency, liquid state, stability, and drug release. The low-energy method hot-melt emulsification was successfully adapted for the manufacturing of small and narrowly dispersed LCMs. The obtained LCMs had a small average size of ~ 11 nm and a narrow polydispersity index (PDI) of 0.228. These nanocarriers were able to increase the amount of NFD dispersible in water more than 700-fold. Due to their sustained drug release profile and the PEGylation of Gelucire 44/14, these nanocarriers represent an excellent starting point for the development of drug delivery systems designed for long circulation times and passive targeting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Nyckelord
- Lipid-core micelles
- Low-energy method
- Poorly water soluble drugs
- Hot-melt emulsification
- Nanocarriers
- Health Science
- Hälsovetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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