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Refined Analysis of...
Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions: Of Use in Targeted Rehabilitative Approaches?
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- Latini, Francesco, Ph.D. 1982- (författare)
- Uppsala University,Uppsala universitet,Enblad: Neurokirurgi
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- Fahlström, Markus (författare)
- Uppsala University,Uppsala universitet,Radiologi
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- Vedung, Fredrik (författare)
- Uppsala University,Uppsala universitet,Enblad: Neurokirurgi
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- Stensson, Staffan (författare)
- Rehabilitation and Pain Centre, Uppsala University Hospital, 75185 Uppsala, Sweden
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- Larsson, Elna-Marie (författare)
- Uppsala University,Uppsala universitet,Radiologi
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- Lubberink, Mark (författare)
- PET Centre, Uppsala University Hospital, 75185 Uppsala, Sweden; Medical Physics, Uppsala University Hospital, 75185 Uppsala, Sweden
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- Tegner, Yelverton, Professor emeritus (författare)
- Luleå University of Technology,Luleå tekniska universitet,Hälsa, medicin och rehabilitering
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- Haller, Sven (författare)
- Uppsala University,Uppsala universitet,Radiologi,Affidea CDRC Centre de Diagnostic Radiologique de Carouge SA, Clos de la Fonderie
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- Johansson, Jakob (författare)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård
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- Wall, Anders (författare)
- Uppsala University,Uppsala universitet,Radiologi,Uppsala University Hospital
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- Antoni, Gunnar (författare)
- Uppsala University,Uppsala universitet,Institutionen för läkemedelskemi
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- Marklund, Niklas (författare)
- Uppsala University,Lund University,Lunds universitet,Uppsala universitet,Enblad: Neurokirurgi,Skåne University Hospital; Lund University,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Forskargrupper vid Lunds universitet,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research,Lund University Research Groups
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(creator_code:org_t)
- 2022-01-12
- 2022
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 11:2
- Relaterad länk:
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https://doi.org/10.3...
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https://ltu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of post-injury regional white matter changes after TBI and rSRC. Six patients with moderate/severe TBI, and 12 athletes with rSRC were included ≥6 months post-injury, and 10 (age-matched) healthy controls (HC) were analyzed. The Repeatable Battery for the Assessment of Neuropsychological Status was performed at the time of DTI. Major white matter pathways were tracked using q-space diffeomorphic reconstruction and analyzed for global and regional changes with a controlled false discovery rate. TBI patients displayed multiple classic white matter injuries compared with HC (p < 0.01). At the regional white matter analysis, the left frontal aslant tract, anterior thalamic radiation, and the genu of the corpus callosum displayed focal changes in both groups compared with HC but with different trends. Both TBI and rSRC displayed worse memory performance compared with HC (p < 0.05). While global analysis of DTI-based parameters did not reveal common abnormalities in TBI and rSRC, abnormalities to the fronto-thalamic network were observed in both groups using regional analysis of the white matter pathways. These results may be valuable to tailor individualized rehabilitative approaches for post-injury cognitive impairment in both TBI and rSRC patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- traumatic brain injury
- sport related concussion
- memory impairment
- diffusion tensor imaging
- white matter lesions
- rehabilitative approaches
- Medicinsk vetenskap
- Medical Science
- Diffusion tensor imaging
- Memory impairment
- Rehabilitative approaches
- Sport related concussion
- Traumatic brain injury
- White matter lesions
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Latini, Francesc ...
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Fahlström, Marku ...
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Vedung, Fredrik
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Stensson, Staffa ...
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Larsson, Elna-Ma ...
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Lubberink, Mark
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visa fler...
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Tegner, Yelverto ...
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Haller, Sven
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Johansson, Jakob
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Wall, Anders
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Antoni, Gunnar
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Marklund, Niklas
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Luleå tekniska universitet
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Uppsala universitet
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Lunds universitet