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Osteogenic markers ...
Osteogenic markers in peri‐implant crevicular fluid in immediate and delayed‐loaded dental implants: A randomized controlled trial
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- Rastogi, Simran (författare)
- Department of Biophysics, All India Institute of Medical Sciences (AIIMS), New Delhi, India
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- Rani, Komal (författare)
- Department of Pathology & Laboratory Medicine, All India Institute of Medical Sciences Bibinagar, Hyderabad, Telangana, India
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- Sharma, Vaibhav (författare)
- Luleå tekniska universitet,Omvårdnad och medicinsk teknik
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- Bharti, Prahalad Singh (författare)
- Department of Biophysics, All India Institute of Medical Sciences (AIIMS), New Delhi, India
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- Deo, Krishna (författare)
- Department of Prosthodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences (AIIMS), New Delhi, India
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- Jain, Veena (författare)
- Department of Prosthodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences (AIIMS), New Delhi, India
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- Nanda, Aditi (författare)
- Department of Prosthodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences (AIIMS), New Delhi, India
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- Kumar, Saroj (författare)
- Luleå tekniska universitet,Omvårdnad och medicinsk teknik,Department of Biophysics, All India Institute of Medical Sciences (AIIMS), New Delhi, India
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- Koli, Dheeraj Kumar (författare)
- Department of Prosthodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences (AIIMS), New Delhi, India
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(creator_code:org_t)
- 2023-03-20
- 2023
- Engelska.
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Ingår i: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1523-0899 .- 1708-8208. ; 25:3, s. 540-548
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https://ltu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- IntroductionThe study evaluates the levels of matrix metalloprotease-8 (MMP-8), and Cathepsin-K (CatK) in peri-implant crevicular fluid (PICF) among patients with immediate loaded (IL) and delayed-loaded (DL) implants at different time points to know the inflammation and osteogenic status.MethodsThe study population consisted of two groups (n = 25, each group) with a mean age of 28.7 ± 3.5 years, and PICF was collected. MMP-8 and CatK levels were quantified through ELISA.ResultsWe observed the concentrations of inflammatory markers (MMP-8 and CatK) at three time points in the IL and DL groups. The mean concentration of MMP-8 in the IL group was 9468 ± 1230 pg/mL, 5547 ± 1088 pg/mL, and 7248 ± 1396 pg/mL at 2 weeks, 3 months, and 12 months, respectively; while in the DL group was 10 816 ± 779.7 pg/mL, 9531 ± 1245 pg/mL, and 9132 ± 1265 pg/mL at 2 weeks, 3 and 12 months, respectively. The mean concentration of Cat-K in the IL group was observed at 422.1 ± 36.46 pg/mL, 242.9 ± 25.87 pg/mL, and 469 ± 75.38 pg/mL at 2 weeks, 3, and 12 months, whereas in the DL group was 654.6 ± 152.9 pg/mL, 314.7 ± 28.29 pg/mL, and 539.8 ± 115.1 pg/mL at 2 weeks, 3 months and 12 months, respectively.ConclusionIn this study, the levels of CatK and MMP-8 levels decline at 12 months in both groups, and the IL group shows lower values compared to the DL group; however, no significant changes were observed after analyses were adjusted for multiple comparisons (p > 0.025). Therefore, there is not much difference observed in the inflammation process between immediate and delayed loading. (Clinical trial identifier: CTRI/2017/09/009668).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Annan medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Other Medical Biotechnology (hsv//eng)
Nyckelord
- biomarkers
- bone formation
- cathepsin K
- dental implants
- inflammation
- matrix metalloprotease
- osteocalcin
- peri-implant crevicular fluid
- Biomedical Engineering
- Medicinsk teknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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