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Sökning: id:"swepub:oai:DiVA.org:mau-17516" > Non-reversible heat...

Non-reversible heat-induced gelation of a biocompatible Fmoc-hexapeptide in water

Wojciechowski, Jonathan P. (författare)
School of Chemistry, The Australian Centre for Nanomedicine and the ARC Centre for Convergent Bio-Nano Science & Technology, University of New South Wales, Sydney, NSW 2052, Australia,Imperial College London
Martin, Adam D. (författare)
Dementia Research Centre, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, 2109, NSW, Australia
Du, Eric Y. (författare)
School of Chemistry, Australian Centre for Nanomedicine, ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, 2052, NSW, Australia
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Garvey, Christopher J. (författare)
Malmö University,Lund University,Lunds universitet,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Australian Nuclear Science and Technology Organisation, New Illawara Rd, Lucas Heights, 2231, NSW, Australia; Lund Institute for Advanced Neutron and X-ray Scattering, Lund, Sweden,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
Nordon, Robert E. (författare)
Graduate School of Biomedical Engineering, University of New South Wales Sydney, Sydney, 2052, NSW, Australia
Thordarson, Pall (författare)
School of Chemistry, Australian Centre for Nanomedicine, ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, 2052, NSW, Australia
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 (creator_code:org_t)
2020
2020
Engelska.
Ingår i: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 12:15, s. 8262-8267
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Hydrogel materials which respond to changes in temperature are widely applicable for injectable drug delivery or tissue engineering applications. Here, we report the unsual heat-induced gelation behaviour of a low molecular weight gelator based on an Fmoc-hexapeptide, Fmoc-GFFRGD. We show that Fmoc-GFFRGD forms kinetically stable fibres when mixed with divalent cations (e.g. Ca2+). Gelation of the mixture occurs upon heating of the mixture which enables electrostatic screening by the divalent cations and hydrophobic collapse of the fibres to give a self-supporting hydrogel network that shows good biocompatibility with L929 fibroblast cells. This work highlights a unique mechanism to initiate heat-induced gelation which should find opportunities as a gelation trigger for injectable hydrogels or fundamental self-assembly applications.

Ämnesord

NATURVETENSKAP  -- Kemi -- Fysikalisk kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Physical Chemistry (hsv//eng)
NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

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