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Multivalent mesopor...
Multivalent mesoporous silica nanoparticles photodelivering nitric oxide with carbon dots as fluorescent reporters
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- Afonso, Damien (författare)
- Laboratory of Photochemistry, Department of Drug Sciences, Viale Andrea Doria 6, 95125, Catania, Italy
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- Valetti, Sabrina (författare)
- Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Nanologica AB, Södertälje, SE-151 36, Sweden
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- Fraix, Aurore (författare)
- Laboratory of Photochemistry, Department of Drug Sciences, Viale Andrea Doria 6, Catania, 95125, Italy
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- Bascetta, Claudia (författare)
- Laboratory of Photochemistry, Department of Drug Sciences, Viale Andrea Doria 6, Catania, 95125, Italy
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- Petralia, Salvatore (författare)
- STMicroelectronics, Stradale Primosole 50, Catania, I-95121, Italy
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- Conoci, Sabrina (författare)
- STMicroelectronics, Stradale Primosole 50, Catania, I-95121, Italy
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- Feiler, Adam (författare)
- Nanologica AB, Södertälje, 151 36, Sweden; Surface and Corrosion Science, KTH Royal Institute of Technology, Stockholm, SE-100 44, Sweden
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- Sortino, Salvatore (författare)
- Laboratory of Photochemistry, Department of Drug Sciences, Viale Andrea Doria 6, Catania, 95125, Italy
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(creator_code:org_t)
- Royal Society of Chemistry, 2017
- 2017
- Engelska.
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Ingår i: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 9
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Amino-terminated mesoporous silica nanoparticles embedding carbon dots (MSCD) formed by calcination were functionalized with a nitric oxide (NO) photodonor (1) to give a robust MSCD-1 conjugate. The intense fluorescence of MSCDs was strongly quenched in MSCD-1 by effective energy transfer. Visible light excitation of MSCD-1 liberates NO, suppresses the energy transfer mechanism and leads to concomitant fluorescence restoration of the MSCD scaffold, which acts as an optical reporter for the released NO. The MSCD-1 hybrid is also able to encapsulate the highly hydrophobic photosensitizer temoporfin, preserving the fluorescence reporting function.
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- art (ämneskategori)
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